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100105 A23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem

A mobile ion-carrier that forms stable complexes with divalent cations.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Calcimycin

100105
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₂₉H₃₇N₃O₆52665-69-7

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                  Description
                  OverviewA mobile ion-carrier that forms stable complexes with divalent cations. Useful for increasing intracellular Ca2+ levels. Also acts as an uncoupler of oxidative phosphorylation and inhibitor of mitochondrial ATPase activity. An antibiotic with weak activity against Gram-positive bacteria. Also induces apoptosis in mouse lymphoma cell line (S49); however, A23187 has been shown to block apoptosis in other systems, such as when interleukin-3 (IL-3) is withdrawn from IL-3-dependent cells.
                  Catalogue Number100105
                  Brand Family Calbiochem®
                  SynonymsCalcimycin
                  References
                  ReferencesCaron-Leslie, L.A., et al. 1994. FASEB J. 8, 639.
                  Saunders, M.J., and Hepler, P.K. 1982. Science 217, 943.
                  Pressman, B.C. 1976. Annu. Rev. Biochem. 45, 501.
                  Pfeiffer, D.R., et al. 1974. Biochemistry 13, 4007.
                  Reed, P.W., and Lardy, H.A. 1972. J. Biol. Chem. 247, 6970.
                  Product Information
                  CAS number52665-69-7
                  ATP CompetitiveN
                  FormWhite solid
                  Hill FormulaC₂₉H₃₇N₃O₆
                  Chemical formulaC₂₉H₃₇N₃O₆
                  ReversibleN
                  Structure formula ImageStructure formula Image
                  Quality LevelMQ100
                  Applications
                  Biological Information
                  Primary TargetMitochondrial ATPase
                  Purity≥98% by TLC
                  Physicochemical Information
                  Cell permeableN
                  Dimensions
                  Materials Information
                  Toxicological Information
                  Safety Information according to GHS
                  RTECSDM4676000
                  Safety Information
                  Product Usage Statements
                  Storage and Shipping Information
                  Ship Code Ambient Temperature Only
                  Toxicity Standard Handling
                  Storage +2°C to +8°C
                  Protect from Light Protect from light
                  Do not freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
                  Packaging Information
                  Transport Information
                  Supplemental Information
                  Specifications

                  Documentation

                  A23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem SDS

                  Title

                  Safety Data Sheet (SDS) 

                  A23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem Certificates of Analysis

                  TitleLot Number
                  100105

                  References

                  Reference overview
                  Caron-Leslie, L.A., et al. 1994. FASEB J. 8, 639.
                  Saunders, M.J., and Hepler, P.K. 1982. Science 217, 943.
                  Pressman, B.C. 1976. Annu. Rev. Biochem. 45, 501.
                  Pfeiffer, D.R., et al. 1974. Biochemistry 13, 4007.
                  Reed, P.W., and Lardy, H.A. 1972. J. Biol. Chem. 247, 6970.

                  Brochure

                  Title
                  Caspases and other Apoptosis Related Tools Brochure
                  Tools and Tips for Analyzing Apoptosis
                  Data Sheet

                  Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

                  Revision07-April-2008 RFH
                  SynonymsCalcimycin
                  DescriptionA mobile ion-carrier that forms stable complexes with divalent cations. Useful for increasing intracellular Ca2+ levels. Also acts as an uncoupler of oxidative phosphorylation and inhibitor of mitochondrial ATPase activity. An antibiotic with weak activity against Gram positive bacteria. Also induces apoptosis in mouse lymphoma cell line (S49); however, A23187 has been shown to block apoptosis in other systems, such as when interleukin-3 (IL-3) is withdrawn from IL-3-dependent cells.
                  FormWhite solid
                  CAS number52665-69-7
                  RTECSDM4676000
                  Chemical formulaC₂₉H₃₇N₃O₆
                  Structure formulaStructure formula
                  Purity≥98% by TLC
                  SolubilityDMSO or Methanol. For use in aqueous systems, preparation of a 100 mM stock in DMSO is recommended. Microliter amounts of this solution can then be added to H₂O with rapid mixing (e.g. 10 µl into 5 ml of H₂O). In aqueous systems, the ionophore aggregates over time.
                  Storage +2°C to +8°C
                  Protect from light
                  Do Not Freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
                  Toxicity Standard Handling
                  Merck USA index14, 1639
                  ReferencesCaron-Leslie, L.A., et al. 1994. FASEB J. 8, 639.
                  Saunders, M.J., and Hepler, P.K. 1982. Science 217, 943.
                  Pressman, B.C. 1976. Annu. Rev. Biochem. 45, 501.
                  Pfeiffer, D.R., et al. 1974. Biochemistry 13, 4007.
                  Reed, P.W., and Lardy, H.A. 1972. J. Biol. Chem. 247, 6970.

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                  Categories

                  Life Science Research > Inhibitors and Biochemicals > Biochemicals > Ionophores