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|US1181315-10MG||Glass bottle||10 mg||
|Overview||A cell-permeable benzothiazinone that is shown to interact with MIF homotrimer (Kd = 68.6 nM and 157 nM toward human and rat MIF, respectively, at pH 7.3) via the N-terminal proline in a pH-dependent manner, limiting its inhibitory capability against MIF tautomerase activity (13% inhibition at pH 6.0; [BTZO-1] = 30 µM) due to reduced MIF binding at acidic pH. Shown to protect primary rat cardiomyocytes (330 nM) from apoptotic death upon serum deprivation or DOX (200 nM; Cat. No. 324380) treatment via activation of ARE- (antioxidant response element) mediated cytoprotective genes transcription in a MIF-dependent manner.|
|Synonyms||2-Pyridin-2-yl-4H-1,3-benzothiazin-4-one, Antioxidant Response Element Activator, Macrophage Migration Inhibitory Factor Antagonist II, MIF Antagonist II|
|References||Kimura, H., et al. 2010. Chem. Biol. 17, 1282.|
|Structure formula Image|
|Purity||≥98% by HPLC|
|Safety Information according to GHS|
|Product Usage Statements|
|Packaged under inert gas||Packaged under inert gas|
ARE Activator, BTZO-1 - Calbiochem SDS
|Kimura, H., et al. 2010. Chem. Biol. 17, 1282.|
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.