114825 Sigma-AldrichAdapalene - CAS 106685-40-9 - Calbiochem
A cell-permeable naphthoic acid compound that exhibits selective affinity and agonistic potency toward RARβ and RARγ over RARα.
More>> A cell-permeable naphthoic acid compound that exhibits selective affinity and agonistic potency toward RARβ and RARγ over RARα. Less<<Adapalene - CAS 106685-40-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: CD271, RAR Agonist V, ADA, Differin, 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid, CD 271
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 106685-40-9 | C₂₈H₂₈O₃ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
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| 114825-25MG | 25 mg |
| Description | |
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| Overview | A cell-permeable naphthoic acid compound that exhibits selective affinity and agonistic potency toward RARβ and RARγ over RARα (Kd = 34, 130, and 1100 nM, respectively; AC50 = 2.3, 9.3, and 22 nM, respectively, in COS-7-based reporter assays) without appreciable affinity toward cytosolic retinoic acid binding proteins CRABP I/II (Kd >> 1 µM) or detectable activity toward RXRα (AC50 > 1 µM). The biological activity and pharmaceutical efficacy of ADA are generally shown to be superior to those of ATRA/Tretinoin (Cat. No. 554720) both in vitro and in vivo. |
| Catalogue Number | 114825 |
| Brand Family | Calbiochem® |
| Synonyms | CD271, RAR Agonist V, ADA, Differin, 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid, CD 271 |
| Product Information | |
|---|---|
| CAS number | 106685-40-9 |
| Form | White solid |
| Hill Formula | C₂₈H₂₈O₃ |
| Chemical formula | C₂₈H₂₈O₃ |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥97% by HPLC |
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| Safety Information according to GHS |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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Documentation
Adapalene - CAS 106685-40-9 - Calbiochem SDS
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Adapalene - CAS 106685-40-9 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 114825 |
References
| Reference overview |
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| Irby, C.E., et al. 2008. J. Adolesc. Health 43, 421. Ocker, M., et al. 2003. Int. J. Cancer 107, 453. Kim, M.J., et al. 2000. J. Invest. Dermatol. 114, 349. Shroot, B., et al. 1997. J. Am. Acad. Dermatol. 36, S96. |
Brochure
| Title |
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| Undisputed Accuracy for Your Quantitative Results |
Technical Info
| Title |
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| Programming data for Spectrophotometer and Spectroquant Test Kits |
Instructions for Use
| Title |
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| Manual Spectroquant Photometer NOVA 60A (english) |
| 114825 - Spectroquant Aluminium Test |
| Analytical Procedures and Appendices Spectroquant Prove 100 |
| Analytical Procedures and Appendices Spectroquant Prove 300 |
| Analytical Procedures and Appendices Spectroquant®Prove 600 |
| Manual Spectroquant Multy - Operating manual |
| Manual Spectroquant Spectrophotometer Pharo 100 |
| Manual Spectroquant Spectrophotometer Pharo 300 |
| Manual Spectroquant®Prove Connect to Dashboard - English |
| Manual Spectroquant®Prove Connect to LIMS - English |