124012 Sigma-AldrichAkt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem
Akt Inhibitor V, Triciribine, CAS 35943-35-2, is a cell-permeable, selective, reversible inhibitor of the cellular phosphorylation/activation of Akt1/2/3.
More>> Akt Inhibitor V, Triciribine, CAS 35943-35-2, is a cell-permeable, selective, reversible inhibitor of the cellular phosphorylation/activation of Akt1/2/3. Less<<Synonyms: NSC 154020, TCN, Akt/PKB Signaling Inhibitor-2, API-2
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Overview
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Key Spec Table
CAS # | Empirical Formula |
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35943-35-2 | C₁₃H₁₆N₆O₄ |
Products
Catalogue Number | Packaging | Qty/Pack | |
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124012-10MG | Glass bottle | 10 mg | |
124012-1MG | Plastic ampoule | 1 mg |
Description | |
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Overview | A cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3. It does not inhibit known upstream activators of Akt, i.e. PI3K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥ 60% in cell proliferation at 20 µM) and in vivo (≥ 80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.). Also available in InSolution™ format (Cat. No. 124038). |
Catalogue Number | 124012 |
Brand Family | Calbiochem® |
Synonyms | NSC 154020, TCN, Akt/PKB Signaling Inhibitor-2, API-2 |
References | |
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References | Karst, A., et al. 2006. Cancer Res. 66, 9225. Yang, L., et al. 2004. Cancer Res. 64, 4394. |
Product Information | |
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CAS number | 35943-35-2 |
ATP Competitive | N |
Form | Solid |
Hill Formula | C₁₃H₁₆N₆O₄ |
Chemical formula | C₁₃H₁₆N₆O₄ |
Reversible | Y |
Structure formula Image | |
Quality Level | MQ100 |
Applications | |
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Application | Akt Inhibitor V, Triciribine, CAS 35943-35-2, is a cell-permeable, selective, reversible inhibitor of the cellular phosphorylation/activation of Akt1/2/3. |
Biological Information | |
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Primary Target | Akt1, Akt 2, Akt3 |
Purity | ≥95% by HPLC |
Physicochemical Information | |
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Cell permeable | Y |
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Materials Information |
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Toxicological Information |
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Safety Information according to GHS | |
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RTECS | RY8455000 |
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Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
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Supplemental Information |
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Specifications |
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Global Trade Item Number | |
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Catalogue Number | GTIN |
124012-10MG | 04055977205640 |
124012-1MG | 04055977205633 |
Documentation
Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem SDS
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Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem Certificates of Analysis
Title | Lot Number |
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124012 |
References
Reference overview |
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Karst, A., et al. 2006. Cancer Res. 66, 9225. Yang, L., et al. 2004. Cancer Res. 64, 4394. |
Brochure
Title |
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Akt |
Biologics 31.1 |