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05-23-2402 Calcitonin, Human

05-23-2402
Purchase on Sigma-Aldrich

Overview

Replacement Information

Products

Catalogue NumberPackaging Qty/Pack
US105232402-0.5MG Plastic ampoule .5 mg
Description
OverviewSynthetic, human calcitonin. A 32 amino acid peptide that is shown to stimulate bone formation and inhibit bone resorption.
Catalogue Number05-23-2402
Brand Family Calbiochem®
References
ReferencesGennari, C. and Agnusdei, D. 1994. Br. J. Clin. Pract. 48, 196.
MacIntyre, I. et al. 1988. Clin. Orthop. 217, 45.
Chambers, T.J., et al. 1985. J. Pathol. 145, 297.
Product Information
CAS number21215-62-3
FormLyophilized
FormulationSold on the basis of peptide content.
Hill FormulaC₁₅₁H₂₂₆N₄₀O₄₅S₃
Chemical formulaC₁₅₁H₂₂₆N₄₀O₄₅S₃
Hygroscopic Hygroscopic
Sold on the basis of peptide contentY
Quality LevelMQ100
Applications
Biological Information
Purity≥96% by HPLC
Physicochemical Information
Peptide ContentY
Peptide SequenceH-Cys¹-Gly-Asn-Leu-Ser-Thr-Cys⁷-Met-Leu-Gly-Thr-Tyr-Thr-Gln-Asp-Phe-Asn-Lys-Phe-His-Thr-Phe-Pro-Gln-Thr-Ala-Ile-Gly-Val-Gly-Ala-Pro-NH₂(disulfide bond: 1 → 7)
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSXP3560000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.



From Catalog:
Desc. Field- added "A 32 amino acid residue peptide that is shown to stimulate bone formation and inhibit bone resorption.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Calcitonin, Human Certificates of Analysis

TitleLot Number
05-23-2402

References

Reference overview
Gennari, C. and Agnusdei, D. 1994. Br. J. Clin. Pract. 48, 196.
MacIntyre, I. et al. 1988. Clin. Orthop. 217, 45.
Chambers, T.J., et al. 1985. J. Pathol. 145, 297.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-September-2008 RFH
DescriptionCalcitonin is a single-chain peptide hormone of 32 amino acid residues with a disulfide bridge between cysteines at positions 1 and 7. It is produced in the parafollicular C cells of the thyroid gland and acts to stimulate bone formation by osteoblasts and inhibits bone resorption. Part of the effect of calcitonin appears to be mediated through increasing cAMP concentrations in osteoclasts.
FormLyophilized
FormulationSold on the basis of peptide content.
CAS number21215-62-3
RTECSXP3560000
Chemical formulaC₁₅₁H₂₂₆N₄₀O₄₅S₃
Peptide SequenceH-Cys¹-Gly-Asn-Leu-Ser-Thr-Cys⁷-Met-Leu-Gly-Thr-Tyr-Thr-Gln-Asp-Phe-Asn-Lys-Phe-His-Thr-Phe-Pro-Gln-Thr-Ala-Ile-Gly-Val-Gly-Ala-Pro-NH₂(disulfide bond: 1 → 7)
Purity≥96% by HPLC
Solubility5% Acetic acid (1 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.



From Catalog:
Desc. Field- added "A 32 amino acid residue peptide that is shown to stimulate bone formation and inhibit bone resorption.
Toxicity Standard Handling
Merck USA index14, 1643
ReferencesGennari, C. and Agnusdei, D. 1994. Br. J. Clin. Pract. 48, 196.
MacIntyre, I. et al. 1988. Clin. Orthop. 217, 45.
Chambers, T.J., et al. 1985. J. Pathol. 145, 297.