344355 Sigma-AldrichFoxo1 Inhibitor, AS1842856 - CAS 836620-48-5 - Calbiochem
Foxo1 Inhibitor, AS1842856, is a cell-permeable inhibitor that blocks the transcription activity of Foxo1 (IC₅₀ = 33 nM). Directly binds to the active Foxo1, but not the Ser256-phosphorylated form.
More>> Foxo1 Inhibitor, AS1842856, is a cell-permeable inhibitor that blocks the transcription activity of Foxo1 (IC₅₀ = 33 nM). Directly binds to the active Foxo1, but not the Ser256-phosphorylated form. Less<<Synonyms: 5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
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Overview
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Key Spec Table
CAS # | Empirical Formula |
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836620-48-5 | C₁₈H₂₂FN₃O₃ |
Products
Catalogue Number | Packaging | Qty/Pack | |
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344355-10MG | Glass bottle | 10 mg |
Description | |
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Overview | A cell-permeable oxodihydroquinoline that preferentially inhibits the transcription activity of Forkhead box O family member Foxo1 (IC50 = 33 nM) over that of the functionally related Foxo3a and Foxo4 (70%, 20%, and 3% inhibition, respectively, in HepG2-based reporter assays; [AS184256] = 100 nM) via direct binding of the active Foxo1, but not the Ser256-phosphorylated/inactive form of Foxo1. Shown to inhibit gluconeogenesis in rat heptoma Fao cultures (IC50 = 43 nM against glucose production) in vitro and in liver of both non-diabetic and diabetic mice during a 26-hour fasting period (100 mg/kg/8 h p.o.) in vivo. Also available as a 50 mM solution in DMSO (Cat. No. 506081). |
Catalogue Number | 344355 |
Brand Family | Calbiochem® |
Synonyms | 5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid |
References | |
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References | Nagashima, T., et al. 2010. Mol. Pharmacol. 78, 961. |
Product Information | |
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CAS number | 836620-48-5 |
Form | Off-white to tan to yellow solid |
Hill Formula | C₁₈H₂₂FN₃O₃ |
Chemical formula | C₁₈H₂₂FN₃O₃ |
Structure formula Image | |
Quality Level | MQ100 |
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Purity | ≥98% by HPLC |
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Packaged under inert gas | Packaged under inert gas |
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Specifications |
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Global Trade Item Number | |
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Catalogue Number | GTIN |
344355-10MG | 07790788059712 |
Documentation
Foxo1 Inhibitor, AS1842856 - CAS 836620-48-5 - Calbiochem SDS
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Foxo1 Inhibitor, AS1842856 - CAS 836620-48-5 - Calbiochem Certificates of Analysis
Title | Lot Number |
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344355 |
References
Reference overview |
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Nagashima, T., et al. 2010. Mol. Pharmacol. 78, 961. |
Brochure
Title |
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New Products: Volume 3, 2012 |