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Cellulose TLC and HPTLC Plates

Precise Analysis of Polar Substances

Cellulose TLC and HPTLC platesThe organic sorbent cellulose is particularly suitable for the separation of hydrophilic substances by partition chromatography. Merck offers cellulose plates for demanding high-performance separations. Based on microcrystalline cellulose, the TLC plates are ideal for standard separations. Whereas the HPTLC plates use high-purity, rod-shaped microcrystalline cellulose, resulting in a highly reduced diffusion of analytes for demanding, high-performance separations.

We also provide special PEI cellulose plates (polyethylenimine-modified cellulose), which act as strong basic anion exchangers. This makes them the best choice for analyzing substances with exchange-active ionic groups, such as amino acids, peptides, nucleotides and nucleosides.

Cellulose plates are available with or without fluorescent indicators. They utilize a special fluorescent pigment that is stimulated to intense blue fluorescent emission by long-wave UV light of 366 nm and by short-wave UV light at 254 nm.


Typical applications of cellulose plates include the analysis of amino acids, carbohydrates, phosphates, nucleic acids and nucleic acid derivatives for:

  • Detection of significantly high increase of amino acids in clinical laboratories
  • 2-dimensional separations such as amino acid “fingerprints”
  • Metabolic studies
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