Process Intensification for Bispecific Antibodies: Flocculated Harvest & Flow-Through Polishing

Karen Chan is the Head of Downstream MSAT at our company, based in Singapore, with over 16 years of experience in the biopharmaceutical industry. Karen has led and contributed to numerous process development, troubleshooting, and collaborative projects with biotech companies in Southeast Asia and Taiwan. Her technical expertise focuses on tangential flow filtration (TFF) and virus-related downstream technologies, with contributions to publications on topics such as single-pass TFF, media filtration, and Quality by Design (QbD). She holds a degree in Chemical Engineering from the National University of Singapore and is a certified Workforce Skills Qualification (WSQ) trainer in Singapore.

Wei-Che Lin has over 10 years of experience in biopharmaceutical development, specializing in downstream processes for mAbs, bispecifics, and recombinant proteins. Through his extensive CDMO background, he has developed a versatile capability in purification development for a wide variety of sample sources. His expertise spans process design, process intensification, and next-generation technologies, with a consistent focus on improving manufacturing efficiency, scalability, and product quality.

Anna Lee is a Technical Application Expert for Downstream technologies for the Process Solutions in Taiwan. She focus on delivering updated information of downstream products and applications. Mostly she provides solutions for bioprocess development and consultancy regarding downstream bioprocess.