05-858R

Anti-Histone H4 Antibody, pan, clone 62-10C-2, rabbit monoclonal

Name: Anti-Histone H4 Antibody, pan, clone 62-10C-2, rabbit monoclonal
Brand: MM

clone 62-10C-2, from rabbit

Synonym(s):

H4, Histone H4, H4 histone family, member A, histone 1, H4a, histone cluster 1, H4a

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About This Item

UNSPSC Code:

12352203

eCl@ss:

32160702

NACRES:

NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

62-10C-2, monoclonal

species reactivity

human

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

NP_003529

UniProt accession no.

P62805

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... H4C1(8359)

General description

Histone H4 is one of the 5 main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N terminal tail H4 is involved with the structure of the nucleosomes of the ′beads on a string′ structure.

10 kDa Observed

Immunogen

Epitope: Epitope mapped to residues 25-28.

KLH-conjugated, synthetic peptide corresponding to amino acids 17-28 of Histone H4.

Application

Use Anti-Histone H4 Antibody, pan, clone 62-10C-2 (Rabbit Monoclonal Antibody) validated in WB to detect Histone H4 also known as Histone H4.

Biochem/physiol Actions

Broad species cross-reactivity expected based on 100% sequence homology to multiple species.

Physical form

Format: Purified

Purified Rabbit Monoclonal IgG Supernatant in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl), containing 40% glycerol with 0.05% sodium azide

Analysis Note

Evaluated by Western Blot in HeLa acid extracts.

Western Blot Analysis: 0.1 µg/ml of this antibody detected histone H4 in 10 µg of HeLa cell lysate.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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hnRNPA2 mediated acetylation reduces telomere length in response to mitochondrial dysfunction.

Manti Guha et al.

PloS one, 13(11), e0206897-e0206897 (2018-11-15)

Telomeres protect against chromosomal damage. Accelerated telomere loss has been associated with premature aging syndromes such as Werner's syndrome and Dyskeratosis Congenita, while, progressive telomere loss activates a DNA damage response leading to chromosomal instability, typically observed in cancer cells

Hydroxamic acid-based histone deacetylase (HDAC) inhibitors can mediate neuroprotection independent of HDAC inhibition.

Sama F Sleiman et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(43), 14328-14337 (2014-10-24)

Histone deacetylase (HDAC) inhibition improves function and extends survival in rodent models of a host of neurological conditions, including stroke, and neurodegenerative diseases. Our understanding, however, of the contribution of individual HDAC isoforms to neuronal death is limited. In this

Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models.

Saravanan S Karuppagounder et al.

Science translational medicine, 8(328), 328ra29-328ra29 (2016-03-05)

Disability or death due to intracerebral hemorrhage (ICH) is attributed to blood lysis, liberation of iron, and consequent oxidative stress. Iron chelators bind to free iron and prevent neuronal death induced by oxidative stress and disability due to ICH, but

Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability.

Benjamin E L Lauffer et al.

The Journal of biological chemistry, 288(37), 26926-26943 (2013-07-31)

Histone deacetylases (HDACs) are critical in the control of gene expression, and dysregulation of their activity has been implicated in a broad range of diseases, including cancer, cardiovascular, and neurological diseases. HDAC inhibitors (HDACi) employing different zinc chelating functionalities such

Global Trade Item Number

SKU	GTIN
05-858R	04053252367939

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