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Merck

06-680-AF647

Anti-Androgen Receptor Antibody, Alexa Fluor™ 647 Conjugate

from rabbit, ALEXA FLUOR™ 647

Synonym(s):

Androgen receptor, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.45
eCl@ss:
32160702

Product Name

Anti-Androgen Receptor Antibody, Alexa Fluor™ 647 Conjugate, from rabbit, ALEXA FLUOR™ 647

biological source

rabbit

conjugate

ALEXA FLUOR™ 647

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rat, human

species reactivity (predicted by homology)

canine (based on 100% sequence homology), bovine (based on 100% sequence homology), mouse (based on 100% sequence homology), horse (based on 100% sequence homology)

technique(s)

immunocytochemistry: suitable

NCBI accession no.

NP_036634

UniProt accession no.

P15207

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

bovine ... Ar(280675)
dog ... Ar(403588)
human ... AR(367)
mouse ... Ar(11835)
rat ... Ar(24208)

Analysis Note

Evaluated by Immunocytochemistry in MCF-7 cells.

Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected Androgen Receptor in MCF-7 cells.

Application

Detect Androgen Receptor using this Anti-Androgen Receptor Antibody, Alexa Fluor™ 647 Conjugate validated for use in Immunocytochemistry.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Hormones & Receptors
The unconjugated antibody (Cat. No. 06-680) is shown to be suitable also for chromatin immunoprecipitation (ChIP), ChIP-seq, Western blotting, immunoprecipitation, flow cytometry, immunohistochemistry applications.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Androgen receptor (UniProt P15207; also known as Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4) is encoded by the Ar (also known as Andr, Nr3c4, Tfm) gene (Gene ID 24208) in rat species. Androgen receptor (AR) is a hormone-activated transcription regulator that plays important roles in normal prostate development and function, as well as in malignant prostate transformation. The binding of an androgenic hormone (testosterone or dihydrotestosterone) induces a conformational change in AR, resulting its dissociation from heat schock proteins and subsequent translocation from the cytosol to nucleus, where it dimerizes and mediates either transcription activation or repression in a target gene-specific manner. The androgen insensitivity syndrome (AIS) or testicular feminization (TFM) is caused by a mutation of the androgen receptor gene located on the X chromosome.
~110 kDa observed.

Immunogen

Epitope: This antibody recognizes the Modulating Region within the N-terminal of androgen receptor.
KLH-conjugated linear peptide corresponding to the N-terminal sequence of rat androgen receptor.

Other Notes

Concentration: Please refer to lot specific datasheet.

Physical form

Affinity purified
Purified rabbit polyclonal antibody conjugate in PBS with 15 mg/mL BSA and 0.1 % sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

Legal Information

ALEXA FLUOR is a trademark of Life Technologies

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Global Trade Item Number

SKUGTIN
06-680-AF64704055977313161

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