14-253-M

p38β2/SAPK2b2 Protein, active, 10 µg

Name: p38β2/SAPK2b2 Protein, active, 10 µg
Brand: MM

Active, N-terminal GST fusion protein corresponding to full length human p38β2/SAPK2b2 activated with MKK6. For use in Kinase Assays.

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About This Item

UNSPSC Code:

12352202

NACRES:

NA.32

eCl@ss:

32160405

Product Name

p38β2/SAPK2b2 Protein, active, 10 µg, Active, N-terminal GST fusion protein corresponding to full length human p38β2/SAPK2b2 activated with MKK6. For use in Kinase Assays.

biological source

human

mol wt

M_w 71 kDa

manufacturer/tradename

Upstate^®

technique(s)

activity assay: suitable (kinase)

Analysis Note

routinely evaluated by phosphorylation of myelin basic protein

Biochem/physiol Actions

Protein Target: p38β2/SAPK2b2

Target Sub-Family: CMGC

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

N-terminal GST fusion protein corresponding to full length human p38β2/SAPK2b2 activated with MKK6.

Product Source: full length human p38β2/SAPK2b2, expressed in E. coli.

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Physical form

Affinity chromatography on glutathione-agarose beads

Preparation Note

6 months at -20°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

GHS07

signalword

Warning

hcodes

H317

pcodes

P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364

Hazard Classifications

Skin Sens. 1

Storage Class

10 - Combustible liquids

wgk

WGK 2

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38).

A Cuenda et al.

The EMBO journal, 16(2), 295-305 (1997-01-15)

Stress-activated protein kinase-3 (SAPK3), a recently described MAP kinase family member with a wide-spread tissue distribution, was transfected into several mammalian cell lines and shown to be activated in response to cellular stresses, interleukin-1 (IL-1) and tumour necrosis factor (TNF)

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1.

A Cuenda et al.

FEBS letters, 364(2), 229-233 (1995-05-08)

A class of pyridinyl imidazoles inhibit the MAP kinase homologue, termed here reactivating kinase (RK) [Lee et al. (1994) Nature 372, 739-746]. We now show that one of these compounds (SB 203580) inhibits RK in vitro (IC50 = 0.6 microM)

Global Trade Item Number

SKU	GTIN
14-253M	04053252283987

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