14-303-M

MKK6/SKK3 Protein, active, 10 µg

Name: MKK6/SKK3 Protein, active, 10 µg
Brand: MM

Active, N-terminal, maltose binding protein tagged, human MKK6/SKK3 fusion protein, amino acids 4-end. For use in Kinase Assays.

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About This Item

UNSPSC Code:

12352202

NACRES:

NA.32

eCl@ss:

32160405

Product Name

MKK6/SKK3 Protein, active, 10 µg, Active, N-terminal, maltose binding protein tagged, human MKK6/SKK3 fusion protein, amino acids 4-end. For use in Kinase Assays.

biological source

human

mol wt

M_w 82 kDa

manufacturer/tradename

Upstate^®

technique(s)

activity assay: suitable (kinase)

Analysis Note

Routinely evaluated by phosphorylation of unactive p38α/SAPK2a.

Biochem/physiol Actions

Protein Target: MKK6

Target Sub-Family: STE

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

N-terminal, maltose binding protein tagged, human MKK6/SKK3 fusion protein, amino acids 4-end.

Product Source: Expressed in E. coli

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Physical form

Amylose Resin Beads

Preparation Note

6 months at -70°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

GHS07

signalword

Warning

hcodes

H317

pcodes

P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364

Hazard Classifications

Skin Sens. 1

Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Cellular stresses and cytokines activate multiple mitogen-activated-protein kinase kinase homologues in PC12 and KB cells.

R Meier et al.

European journal of biochemistry, 236(3), 796-805 (1996-03-15)

The identities of the upstream activators of the mitogen-activated protein (MAP) kinase homologues termed stress-activated-protein (SAP) kinase-1 (also known as JNK or SAPK) and SAP kinase-2 (also known as p38, RK and CSBP) were investigated in rat PC12 cells and

Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases.

M Goedert et al.

The EMBO journal, 16(12), 3563-3571 (1997-06-01)

A cDNA was cloned that encodes human stress-activated protein kinase-4 (SAPK4), a novel MAP kinase family member whose amino acid sequence is approximately 60% identical to that of the other three SAP kinases which contain a TGY motif in their

Global Trade Item Number

SKU	GTIN
14-303M	04053252731310

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