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Merck

23-032-M

MDM2/CK1δ Protein, active, 10 µg

Active, full length, recombinant human MDM2 (N-terminal GST-tagged) combined in vitro with CK1δ, active (Item # 14-520). For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.

Synonym(s):

Double minute 2 protein, p53-binding protein Mdm2, Hdm2

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.41
eCl@ss:
32160405

Product Name

MDM2/CK1δ Protein, active, 10 µg, Active, full length, recombinant human MDM2 (N-terminal GST-tagged) combined in vitro with CK1δ, active (Item # 14-520). For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.

biological source

human

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable

GenBank accession no.

AF527840

Quality Level

300

Application

Ubiquitination Cascade Comoponent: E3

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

MDM2 is an E3 ubiquitin ligase that regulates the turnover of several cellular factors including the p53 tumour suppressor protein and notably MDM2 itself. The suppression of p53 activity by an amplified Mdm2 gene has been observed in many tumours, including soft tissue sarcomas, osteosarcomas and breast tumours.
N-terminal GST-tagged, recombinant human TRAF6 full length, expressed in E.coli.

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Physical form

Purified using glutathione sepharose followed by gel filtration.

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H317

Hazard Classifications

Skin Sens. 1

Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Global Trade Item Number

SKUGTIN
23-032M04053252294488

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