23-060-M
IKKγ
Synonym(s):
NF-kappa-B essential modulator. Inhibitor of nuclear factor kappa-B kinase subunit gamma, FIP-3, NEMO, IKKg
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.41
eCl@ss:
32160405
Application
Ubiquitination Cascade Comoponent: Substrate
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
IKKγ has been shown to play a critical role in NF-κB activation, as the regulatory subunit of IκB kinase, which phosphorylates inhibitors of NF-κB leading to their degradation. Upon cell stimulation, IKKγ can be modified by Lys-63-linked or linear polyubiquitination, both of which are suggested to play key roles in cell signalling, including NF-κB activation. One of the E3 ligases responsible for Lys-63-linked IKKγ polyubiquitination is TRAF6, which participates in several signalling pathways controlling immunity, skin development, osteoclast formation and brain functions.
Physical form
Purified using glutathione sepharose.
Legal Information
GenBank is a registered trademark of United States Department of Health and Human Services
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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Warning
hcodes
Hazard Classifications
Skin Sens. 1
Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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