AB10418

Anti-Puma BH3 domain Antibody

Name: Anti-Puma BH3 domain Antibody
Brand: MM

from rabbit

Synonym(s):

BCL2 binding component 3, Bcl-2 binding component 3, p53 up-regulated modulator of apoptosis

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About This Item

UNSPSC Code:

12352203

eCl@ss:

32160702

NACRES:

NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse

technique(s)

western blot: suitable

NCBI accession no.

NP_055232

UniProt accession no.

Q9BXH1

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

mouse ... Bbc3(170770)

General description

21 kDa

PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis

Immunogen

This antibody was developed against a synthetic peptide selected from the C-terminal region of human Puma.

Application

Anti-Puma BH3 domain Antibody is an antibody against Puma BH3 domain for use in WB.

Biochem/physiol Actions

Other species have not been tested.

The antibody reacts with the 21 kDa Puma BH3 domain protein.

Physical form

Format: Purified

Analysis Note

Control
Western Blot : Mouse brain lysate

Western Blot Analysis: 1:250 dilution of this antibody detected Puma BH3 domain on mouse brain lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A Combination of Podophyllotoxin and Rutin Attenuates Radiation Induced Gastrointestinal Injury by Negatively Regulating NF-κB/p53 Signaling in Lethally Irradiated Mice.

Bhargab Kalita et al.

PloS one, 11(12), e0168525-e0168525 (2016-12-31)

Development of an effective radio protector to minimise radiation-inflicted damages have largely failed owing to inherent toxicity of most of the agents examined so far. This study is centred towards delivering protection to lethally irradiated mice by pre-administration of a

Global Trade Item Number

SKU	GTIN
AB10418	04053252401305

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