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Key Documents

AB10439

Sigma-Aldrich

Anti-PACSIN1 Antibody, NT

from rabbit

Synonym(s):

protein kinase C and casein kinase substrate in neurons 1, syndapin I

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, mouse

technique(s)

immunohistochemistry: suitable (paraffin)
western blot: suitable

UniProt accession no.

Q9BY11

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... PACSIN1(29993)

General description

PACSINs, also known as syndapins, are a protein family consisting of three members that have been implicated in synaptic vesicular membrane trafficking and regulation of dynamin-mediated endocytotic processes (Cuajungco, 2006). It is presumed that all isoforms bind Dynamin, Synaptojanin 1 and N-WASP through their Src homology 3 domains. While PACSIN1 appears to be restricted to neural tissues, two PACSINs are more widespread with PACSIN2 being ubiquitously expressed and PACSIN3 present mainly in skeletal muscle, heart and lung (Modregger, 2001). PACSIN1 has been implicated as playing a central role in synaptic vesicle recycling (Kessels, 2004). Expected molecular weight is 51 kDa.
~57 kDa

Immunogen

KLH conjugated synthetic peptide selected from the N-terminal region of human PACSIN1.

Application

Anti-PACSIN1 Antibody, N-terminus detects level of PACSIN1 & has been published & validated for use in WB, IH(P).

Biochem/physiol Actions

Reactivity with other species has not been tested.
The antibody recognizes human PACSIN1.

Physical form

Format: Purified
PBS containing 0.09% NaN3.

Preparation Note

Maintain at 2-8ºC for up to 6 months from date of receipt. -20ºC is recommended for long term storage.

Analysis Note

Evaluated on a representative lot by Western blot on mouse brain lysate using a 1:100 - 1:500 dilution of Anti-PACSIN1.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Jens Stepan et al.
Cell reports, 41(10), 111766-111766 (2022-12-09)
Learning and memory rely on changes in postsynaptic glutamergic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type receptor (AMPAR) number, spatial organization, and function. The Hippo pathway component WW and C2 domain-containing protein 1 (WWC1) regulates AMPAR surface expression and impacts on memory performance. However

Global Trade Item Number

SKUGTIN
AB1043904053252472381

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