AB15138
Anti-Nogo Receptor Antibody
from rabbit
Synonym(s):
Reticulon-4 receptor, Nogo receptor, NgR, Nogo-66 receptor, Nogor, Rtn4r
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Product Name
Anti-Nogo Receptor Antibody, from rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse, human, rat
technique(s)
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
mouse ... Rtn4R(65079)
Analysis Note
Control
Mouse cerebellum lysate
Mouse cerebellum lysate
Routinely tested on mouse cerebellum lysate.
Lot Specific Tested Application 1: Western Blot
Lot Specific Tested Application 1: Western Blot
Application
Anti-Nogo Receptor Antibody detects level of Nogo Receptor & has been published & validated for use in WB, IH.
Non-Lot Specific Tested Application 1:
Immunohistochemistry: Working dilutions of 1:50-1:500 in rat brain and spinal cord (paraffin embedded)
Immunohistochemistry: Working dilutions of 1:50-1:500 in rat brain and spinal cord (paraffin embedded)
Research Category
Neuroscience
Neuroscience
Research Sub Category
Growth Cones & Axon Guidance
Growth Cones & Axon Guidance
Biochem/physiol Actions
Cat. # AB15138 recognizes the mature form of Nogo Receptor.
May react with human and primate based on sequence homology. Reactivity with other species has not been determined.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Axons are essential for neuronal communication but they do not regenerate after injury to the adult mammalian brain or spinal cord. Failed regeneration is due in part to the production of a potent axonal growth inhibitor, Nogo, by myelinating cells. The finding of a high affinity axonal receptor for the extracellular domain of Nogo provides the first insight into the basis of Nogo action. Disrupting the interaction of Nogo with the Nogo-66 receptor may facilitate axonal regeneration in vivo. The protein is dubbed the Nogo receptor because it binds with several other proteins that block neural growth. It is found to be ubiquitous in the brain and spinal cord.
~50.9 kDa
Immunogen
Epitope: Mature Form
Recombinant protein.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Physical form
Format: Purified
Protein A purified
Purified in PBS with 0.1% NaN3
Preparation Note
Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.
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Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Jian-Tao Liu et al.
Experimental and therapeutic medicine, 22(6), 1413-1413 (2021-10-23)
Methylprednisolone (MP) is widely used to treat clinical spinal cord injury (SCI). Treadmill training is also considered an important treatment after SCI to improve motor function in patients, resulting in an evident improvement. Therefore, the present study was designed to
Hongyan An et al.
Journal of cell science, 129(6), 1198-1209 (2016-01-31)
Inhibitory proteins, particularly Nogo 66, a highly conserved 66-amino-acid loop of Nogo A (an isoform of RTN4), play key roles in limiting the intrinsic capacity of the central nervous system (CNS) to regenerate after injury. Ligation of surface Nogo receptors
Daniela Talhada et al.
International journal of molecular sciences, 22(19) (2021-10-14)
Dopaminergic treatment in combination with rehabilitative training enhances long-term recovery after stroke. However, the underlying mechanisms on structural plasticity are unknown. Here, we show an increased dopaminergic innervation of the ischemic territory during the first week after stroke induced in
Global Trade Item Number
| SKU | GTIN |
|---|---|
| AB15138 | 04053252625527 |
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