AB1520
Anti-Glutamate Transporter Antibody, neuronal
serum, Chemicon®
Synonym(s):
EAAC1, EAAT3
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
biological source
goat
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
rat, mouse, guinea pig
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry: suitable
suitability
not suitable for Western blot
NCBI accession no.
UniProt accession no.
shipped in
dry ice
Gene Information
human ... SLC1A1(6505)
Immunogen
Synthetic peptide from the carboxy-terminus of the cloned rat EAAC1.
Application
Anti-Glutamate Transporter Antibody, neuronal detects level of Glutamate Transporter & has been published & validated for use in IH.
Immunohistochemistry: 1:4,000-8,000 using a cyanine-conjugated secondary antibody. Enzymatic methods of detections can be used, however antibody dilution must be increased to 1:10,000-1:30,000. Lightly fixed, 4% PFA material is recommended. The use of triton X-100 in the block only is recommended.
This antibody is not recommended for use in Western blot.
Optimal working dilutions must be determined by the end user.
This antibody is not recommended for use in Western blot.
Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurotransmitters & Receptors
Neurotransmitters & Receptors
Biochem/physiol Actions
Neuronal Glutamate Transporter (EAAC1; also called EAAT3). The antibody has been tested on central nervous system tissue. The staining pattern for the cell bodies obtained with AB1520 corresponds to the pattern described using in situ hybridization with probes to rEAAC1 mRNA. The immunoreactivity corresponds to what has been described for glutamatergic neuronal systems. Preabsorption of the antiserum with the immunogen peptide completely abolishes the immunostaining.
Physical form
Goat antiserum. Liquid, no preservatives.
Preparation Note
Maintain at -20°C in undiluted aliquots for up to one year.
Avoid repeated freeze/thaw cycles.
Avoid repeated freeze/thaw cycles.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10-13 - German Storage Class 10 to 13
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Maria Collin et al.
The European journal of neuroscience, 18(5), 1265-1278 (2003-09-06)
After synaptic release, glutamate is taken up by the nerve terminal via a plasma membrane-associated protein termed excitatory amino acid transporter 3 (EAAT3). Following entry into the nerve terminal, glutamate is pumped into synaptic vesicles by a vesicular transport system.
Zhongliang Sun et al.
Korean journal of anesthesiology, 70(3), 335-340 (2017-06-06)
Neonatal exposure to anesthetics induces neuronal apoptosis and long-term cognitive dysfunction in rodents. We showed that the nicotinamide adenine dinucleotide phosphate-oxidase inhibitor apocynin not only reduces neurotoxicity by decreasing superoxide levels and preventing mitochondrial dysfunction but also improves long-term memory
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