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Key Documents

AB15508

Sigma-Aldrich

Anti-Iron Regulatory Protein 2 Antibody

Chemicon®, from rabbit

Synonym(s):

IRP-2

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse, human, rat

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable
western blot: suitable

NCBI accession no.

NM_004136.2

UniProt accession no.

P48200

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... IREB2(3658)

General description

Iron regulatory proteins (IRP-1 and IRP-2) are cytoplasmic mRNA-binding proteins that control intracellular iron levels by regulating the translation of ferritin, Tfrs, and other proteins congaing iron-responsive element (IRE) located at the 5′-UTR. IRP binds to IREs with high affinity in situation of iron starvation. Binding of IRP to IRE of ferritin represses its transcription. However, when cells are iron replete, IRPs lose their capacity to bind IREs, allowing efficient translation of ferritin and reducing Tfr mRNA half-life. Although IRP1 and IRP-2 share significant protein sequence homology, they differ in tissue distribution and mode of regulation. IRP-2/IRE-BP2 (rat/human 963 aa) is relatively less abundant than IRP-1 and lacks aconitase activity. It has a unique 73-aa insertion in the N-terminus. In the presence of high iron levels, IRP-2 is rapidly targeted to proteasome-mediated degradation. Although, both IRPs bind the consensus IREs, it is also shown that IRP-2 can recognize an exclusive IRE subset.

Immunogen

Synthetic peptide near the N-terminus of human/rat/mouse IRP-2.

Application

Detect Iron Regulatory Protein 2 using this Anti-Iron Regulatory Protein 2 Antibody validated for use in ELISA & WB.

Biochem/physiol Actions

Iron regulatory protein 2 (IRP-2). The immunogen sequence has no significant homology with IRP-1.
The immunogen sequence is 100% conserved in human, rat, and mouse IRP-2.

Physical form

Format: Purified
Liquid in PBS with 0.1% BSA and 0.05% sodium azide.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Aging-related changes in the iron status of skeletal muscle.
DeRuisseau, KC; Park, YM; DeRuisseau, LR; Cowley, PM; Fazen, CH; Doyle, RP
Experimental Gerontology null
Gurugirijha Rathnasamy et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(49), 17982-17995 (2011-12-14)
This study was aimed to examine the role of iron in causing periventricular white matter (PWM) damage following a hypoxic injury in the developing brain. Along with iron, the expression of iron regulatory proteins (IRPs) and transferrin receptor (TfR), which

Global Trade Item Number

SKUGTIN
AB1550804053252276255

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