Anti-Survivin Antibody, NT

Anti-Survivin Antibody, N-terminus detects level of Survivin & has been published & validated for use in WB.

Research Category
Apoptosis & Cancer

Research Sub Category
BCL2 & Inhibition

Western blot: 0.5 to 1 μg/mL.

MOLT4 cell lysate can be used as positive control and an approximate 17 kDa band should be detected.

Optimal working dilutions must be determined by end user.

Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel IAP protein was recently identified and designated survivin, apoptosis inhibitor 4 (API4) and TIAP1-3. Survivin/TIAP interacted with the processed form of caspase-3 and inhibited its proteolytic activity. Survivin/TIAP is predominantly expressed in tissues of embryos, transformed cell lines, and many human cancers and lymphomas (Ambrosini et al. 1997).

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Epitope: N-terminus

Rabbit anti-Survivin (N-terminal) polyclonal antibody was raised against a peptide corresponding to amino acids 1 to 12 of human origin (Ambrosini et al. 1997).

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Format: Purified

Purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide.

Maintain at 2-8°C in undiluted aliquots for up to 12 months.

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