AB1871
Anti-Caspase 1 Antibody
Chemicon®, from rabbit
Synonym(s):
ICE
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, IP, WB
Citations:
29
biological source
rabbit
conjugate
unconjugated
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human, rat, mouse
manufacturer/tradename
Chemicon®
technique(s)
immunofluorescence: suitable, immunoprecipitation (IP): suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... CASP1(834)
mouse ... Casp1(12362)
rat ... Casp1(25166)
General description
Caspase-1 (ICE, interleukin-1b-converting enzyme) is the mammalian caspase responsible for the proteolytic conversion of the proforms of interleukin-1b and IL-18 into active cytokines. Like other caspases, caspase-1 itself is synthesized as a proenzyme that is cleaved during activation into large (20 kDa) and small (10 kDa) subunits.
Application
Western blot: 1-4 μg/mL
Immunoprecipitation: 4-8 μg/mL
Immunofluorescence: 10-20 μg/mL
Optimal working dilutions must be determined by end user.
Immunoprecipitation: 4-8 μg/mL
Immunofluorescence: 10-20 μg/mL
Optimal working dilutions must be determined by end user.
This Anti-Caspase 1 Antibody is validated for use in IF, IP, WB for the detection of Caspase 1.
Biochem/physiol Actions
AB1871 recognizes the 45 kDa procaspase-1 as well as the 20 kDa cleaved caspase-1.
Physical form
Affinity purified immunoglobulin. Liquid in PBS, pH 7.2, containing 50% glycerol, 1% BSA and 0.02% sodium azide.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
10 - Combustible liquids
wgk
WGK 2
Certificates of Analysis (COA)
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Related Content
Yan Wang et al.
The Journal of international medical research, 48(8), 300060520949767-300060520949767 (2020-09-01)
The inhibition of pyroptosis has a protective effect in sepsis-associated encephalopathy (SAE). However, the mechanisms underlying pyroptosis in SAE remain to be elucidated. Here, we investigated the effects of the caspase inhibitors, Belnacasan (Beln) and Wedelolactone (Wede), on an induced
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