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Key Documents

AB3478

Sigma-Aldrich

Anti-Defensin β3 Antibody

Chemicon®, from rabbit

Synonym(s):

BD-3, hBD-3

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable
western blot: suitable

NCBI accession no.

NM_018661.3

UniProt accession no.

P81534

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... DEFB103A(414325), DEFB103B(414325)

General description

Beta Defensin-3 is a novel 5 kDa nonhemolytic antimicrobial protein peptide which may be important in the innate epithelial defense of infections by various microorganisms seen in skin and lung (such as cystic fibrosis).

Immunogen

A synthetic peptide consisting of amino acids 23-33 [GIINTLQKYYC] of the human beta-defensin-3 protein.

Application

Anti-Defensin Antibody, β3 is an antibody against Defensin for use in ELISA & WB.
Research Category
Inflammation & Immunology
Research Sub Category
Immunoglobulins & Immunology
Western blotting: Tricine-SDS- PAGE gels recommended: 1:500-1:1,000, migrates as a 5-6kDa band; Tricine-SDS-urea PAGE gels: Native Beta Defensin 3 migrates as a 9kDa band; the larger size is because of the reduction of the three cysteine bridges present in the peptide protein

Optimal working dilutions must be determined by the end user.

Biochem/physiol Actions

Recognizes the 5-6 kDa human Defensin-3, beta protein.

Physical form

Format: Purified
Purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide.

Preparation Note

Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Seiko Takeda et al.
Journal of toxicologic pathology, 26(1), 35-40 (2013-06-01)
Defensins are generally implicated in the quick resistance of epithelial surfaces to microbials; however, recent reports have indicated that defensins also have unknown purposes in relation to noninfectious diseases. In this study, the localization patterns of anti-microbial peptides, β defensins

Global Trade Item Number

SKUGTIN
AB347804053252676376

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