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Key Documents

AB3610

Sigma-Aldrich

Anti-Survivin Antibody

serum, Chemicon®

Synonym(s):

TIAP

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

NCBI accession no.

NM_001012270.1
NM_001012271.1
NM_001168.2

UniProt accession no.

O15392

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... BIRC5(332)

General description

Apoptosis is triggered by a variety of stimuli, including members of the Tumor Necrosis Factor (TNF) family, and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. One of these IAP proteins, Survivin/TIAP, interacts with the processed form of caspase-3 and has been shown to inhibit its proteolytic activity. Survivin/TIAP is predominantly expressed in tissues of embryos, transformed cell lines, and many human cancers and lymphomas.

Immunogen

Recombinant, GST-tagged full length human Survivin

Application

Immunoblotting: Recommended antibody dilution 1:3000-6000

Immunoprecipitation: Recommended antibody dilution 1:200

Immunohistochemisty: Recommended antibody dilution 1:1500

Optimal antibody dilutions must be determined by end-user.
This Anti-Survivin Antibody is validated for use in WB, IP, IH for the detection of Survivin.

Physical form

Serum with no preservatives

Preparation Note

Maintain at -20°C for up to 6 months after date of receipt.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Inhibition of IL-6 expression in LNCaP prostate cancer cells by a combination of atorvastatin and celecoxib.
Wang, H; Cui, XX; Goodin, S; Ding, N; Van Doren, J; Du, Z; Huang, MT; Liu, Y; Cheng et al.
Oncology Reports null
Oral Free Paper Sessions.
Virchows Archiv : an international journal of pathology, 469 Suppl 1, 1-346 (2016-08-25)
Linfei Hu et al.
Cell death & disease, 13(2), 124-124 (2022-02-10)
The use of the BRAF inhibitor vemurafenib exhibits drug resistance in the treatment of thyroid cancer (TC), and finding more effective multitarget combination therapies may be an important solution. In the present study, we found strong correlations between Ref-1 high

Global Trade Item Number

SKUGTIN
AB361004053252280184

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