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Key Documents

AB4254

Sigma-Aldrich

Anti-Proteinase-Activated Receptor 2 Antibody, NT, extracellular

Chemicon®, from rabbit

Synonym(s):

PAR-2

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable (paraffin)

NCBI accession no.

NM_005242.3

UniProt accession no.

P55085

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... F2RL1(2150)

General description

The Proteinase-activated receptor 2 (PAR2) is a member of the proteinase-activated receptor subfamily. It is activated through proteolytic exposure of an occult tethered ligand by trypsin and trypsin-like proteases. This is in contrast to other members of the subfamily which are activated by the protease thrombin. PAR2 has been implicated in acute inflammatory response, asthma, and pain transmission. PAR2 expression has been documented in the periphery. ESTs have been isolated from adrenal, brain, breast, heart/melanocyte/uterus, kidney, lung, and vessel libraries.

Immunogen

Epitope: N-terminal, extracellular
Synthetic peptide corresponding to a sequence within the N-terminal extracellular domain of human PAR2. The immunogen has 70% homology with mouse and 60% homology with rat.

Application

Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)

Optimal working dilutions must be determined by the end user.
Research Category
Inflammation & Immunology
Research Sub Category
Inflammation & Autoimmune Mechanisms
This Anti-Proteinase-Activated Receptor 2 Antibody, N-terminal, extracellular is validated for use in IH(P) for the detection of Proteinase-Activated Receptor 2.

Biochem/physiol Actions

Recognizes human PAR2. The specificity of this antibody has been confirmed by IHC staining of human pancreas.

Physical form

Peptide-affinity purified immunoglobulin. Liquid in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide

Preparation Note

Maintain at -70°C in undiluted aliquots for up to 12 months from date of receipt. May be stored at 2-8°C for short term use. Avoid repeated freeze/thaw cycles.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Global Trade Item Number

SKUGTIN
AB425404053252516115

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