Key Documents
AB5060
Anti-Substance P Receptor Antibody, pain
serum, Chemicon®
Synonym(s):
NK-1 Receptor
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All Photos(2)
About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
rat, guinea pig, mouse
manufacturer/tradename
Chemicon®
technique(s)
immunofluorescence: suitable
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... TAC1(6863)
General description
35 kDa
Substance P is a tachykinin family neuropeptide that functions as a neurotransmitter and neuromodulator. In the CNS, Substance P is involved in the regulation of mood, anxiety, sleep, saiety, reinforcement, respiratory rhythm and pain processing. In nociception, the neuropeptide is released at local spinal cord synapses. Recent research now shows substance P is potentially involved in endothelial cell differentiation as well as diverse roles in neuroinflammatory response. The endogenous receptor for Substance P is neurokinin 1 receptor (NK1 receptor), which belongs to the tachykinin receptor sub-family of GPCRs.
Immunogen
Epitope: C terminus
Synthetic peptide that corresponds to a 23 amino acid sequence (385-407) of the COOH terminus of the rat Substance P Receptor (NK-1).
Application
Anti-Substance P Receptor Antibody, pain detects level of Substance P Receptor & has been published & validated for use in IF, IH & WB.
Immunohistochemistry:
A previous lot was used at 1:100-1:1,000 dilution.
Western Blot Analysis:
A previous lot was used at 1:500 dilution.
Optimal working dilutions must be determined by the end user.
A previous lot was used at 1:100-1:1,000 dilution.
Western Blot Analysis:
A previous lot was used at 1:500 dilution.
Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neuroinflammation & Pain
Neuroinflammation & Pain
Biochem/physiol Actions
Specific for the Substance P Receptor (NK-1).
Physical form
Rabbit polyclonal serum containing no preservative.
Unpurified
Preparation Note
Stable for 1 year at -20ºC from date of receipt.
Analysis Note
Control
Spinal Cord, brain membrane lysate
Spinal Cord, brain membrane lysate
Evaluated by western blot on Mouse brain membrane lysates.
Western Blot Analysis:
1:500 dilution of this antibody detected NK-1R on 10 μg of Mouse brain membrane lysates.
Western Blot Analysis:
1:500 dilution of this antibody detected NK-1R on 10 μg of Mouse brain membrane lysates.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Replaces: AB5800
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Yanyan Zhang et al.
International journal of oral science, 11(3), 24-24 (2019-09-11)
Inflammatory orofacial pain, in which substance P (SP) plays an important role, is closely related to the cross-talk between trigeminal ganglion (TG) neurons and satellite glial cells (SGCs). SGC activation is emerging as the key mechanism underlying inflammatory pain through
Terminal field and firing selectivity of cholecystokinin-expressing interneurons in the hippocampal CA3 area.
Lasztoczi, B; Tukker, JJ; Somogyi, P; Klausberger, T
The Journal of Neuroscience null
L Sosulina et al.
Journal of neurophysiology, 114(4), 2500-2508 (2015-09-04)
Substance P (SP) is implicated in stress regulation and affective and anxiety-related behavior. Particularly high expression has been found in the main output region of the amygdala complex, the central amygdala (CE). Here we investigated the cellular mechanisms of SP
Wenling Chen et al.
Neuropharmacology, 128, 255-268 (2017-10-19)
The interaction between NMDA receptors and μ-opioid receptors in primary afferent terminals was studied by using NMDA to induce substance P release, measured as neurokinin 1 receptor internalization. In rat spinal cord slices, the μ-opioid receptor agonists morphine, DAMGO and
Y Muto et al.
British journal of pharmacology, 166(3), 1047-1057 (2011-12-23)
The locus coeruleus (LC) is a major source of noradrenergic projections to the dorsal spinal cord, and thereby plays an important role in the modulation of nociceptive information. The LC receives inputs from substance P (SP)-containing fibres from other regions
Global Trade Item Number
| SKU | GTIN |
|---|---|
| AB5060 | 04053252287633 |
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