AB5464
Anti-Synuclein Antibody, pan
CHEMICON®, rabbit polyclonal
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Product Name
Anti-Synuclein Antibody, pan, serum, Chemicon®
biological source
rabbit
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human, rat
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry: suitable (paraffin), western blot: suitable
NCBI accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... SNCA(6622)
Immunogen
Peptide corresponding to the amino acids 11-26 of human a, b, and g (82%)-synuclein protein. The peptide was chosen so that the antibody would recognize all three forms of synuclein.
Application
Detect Synuclein using this Anti-Synuclein Antibody, pan validated for use in WB, IH(P).
Western blot: 1:1,000.
Immunohistochemistry: 1:1,000 on frozen and paraffin embedded tissue.
Optimal working dilutions must be determined by end user.
Immunohistochemistry: 1:1,000 on frozen and paraffin embedded tissue.
Optimal working dilutions must be determined by end user.
Biochem/physiol Actions
Pan synuclein. Initial testing by immunohistochemistry indicates that the antibody staining pattern overlaps alpha, beta, and gamma-synuclein maps.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Li-Wen Ko et al.
Journal of neuropathology and experimental neurology, 67(11), 1084-1096 (2008-10-30)
Filamentous alpha-synuclein (alpha-syn) aggregates form Lewy bodies (LBs), the neuropathologic hallmarks of Parkinson disease and related alpha-synucleinopathies. To model Lewy body-associated neurodegeneration, we generated transfectant 3D5 of human neuronal-type in which expression of human wild-type alpha-syn is regulated by the
Peizhou Jiang et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 22(9), 3165-3174 (2008-05-22)
The accumulation of filamentous alpha-synuclein (alpha-S) is associated with Parkinson's disease. It remains controversial as to the mode (antiparallel or parallel) of alpha-S self-assembly and whether an exact alignment of the central hydrophobic region is essential. In the present study
Jochen Klucken et al.
Autophagy, 8(5), 754-766 (2012-06-01)
Synucleinopathies like Parkinson disease and dementia with Lewy bodies (DLB) are characterized by α-synuclein aggregates within neurons (Lewy bodies) and their processes (Lewy neurites). Whereas α-synuclein has been genetically linked to the disease process, the pathological relevance of α-synuclein aggregates