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Merck

AB5561

Anti-GABA A Receptor β2 Antibody, cytoplasmic loop

Chemicon®, from rabbit

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

Product Name

Anti-GABA A Receptor β2 Antibody, cytoplasmic loop, Chemicon®, from rabbit

biological source

rabbit

conjugate

unconjugated

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rat, mouse, bovine, human

manufacturer/tradename

Chemicon®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

NCBI accession no.

NM_000813.2
NM_021911.2

UniProt accession no.

P47870

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... GABRB2(2561)

Application

Anti-GABA A Receptor β2 Antibody, cytoplasmic loop is an antibody against GABA A Receptor β2 for use in IP & WB.
Western blot: 1:1,000

Immunopreciptation: The antibody will immunoprecipitate 68% of all GABAA receptors in dodecylsulfate extracts of rat forebrains (150 μL) using 15 μg of antibody.

Optimal working dilutions must be determined by the end user.

Biochem/physiol Actions

GABAA receptor beta2 subunit. The antibody is specific for the ~50 to 56kDa in rat brain membrane fractions.

Immunogen

MBP fusion protein from the cytosolic loop of rat GABAA receptor beta2 subunit.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk

WGK 2

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Evangelos Sotiriou et al.
Journal of neuroscience research, 82(5), 690-700 (2005-11-08)
Recent data demonstrate weaker gamma-aminobutyric acid (GABA)-ergic inhibition in ventral (VH) compared with dorsal (DH) hippocampus. Therefore, we examined possible differences regarding the GABAA receptors between VH and DH as follows: 1) the expression of the GABAA receptor subunits (alpha1/2/4/5
GABA(A) receptor alpha1 subunit mutation A322D associated with autosomal dominant juvenile myoclonic epilepsy reduces the expression and alters the composition of wild type GABA(A) receptors.
Ding, L; Feng, HJ; Macdonald, RL; Botzolakis, EJ; Hu, N; Gallagher, MJ
The Journal of Biological Chemistry null
Altered cortical GABAA receptor composition, physiology, and endocytosis in a mouse model of a human genetic absence epilepsy syndrome.
Zhou, C; Huang, Z; Ding, L; Deel, ME; Arain, FM; Murray, CR; Patel, RS; Flanagan, CD; Gallagher, MJ
The Journal of Biological Chemistry null
George E Farmer et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 315(5), R972-R982 (2018-08-30)
The median preoptic nucleus (MnPO) is an integrative site involved in body fluid homeostasis, cardiovascular control, thermoregulation, and sleep homeostasis. Angiotensin II (ANG II), a neuropeptide shown to have excitatory effects on MnPO neurons, is of particular interest with regard
Jingjing Duan et al.
Frontiers in cellular neuroscience, 13, 217-217 (2019-06-25)
In the adult brain GABAA receptors (GABAARs) mediate the majority of synaptic inhibition that provides inhibitory balance to excitatory drive and controls neuronal output. In the immature brain GABAAR signaling is critical for neuronal development. However, the cell-autonomous role of
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Global Trade Item Number

SKUGTIN
AB556104053252671500

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