Key Documents
AB5609
Anti-GABA A Receptor α1 Antibody, cytoplasmic loop
Chemicon®, from rabbit
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
biological source
rabbit
conjugate
unconjugated
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
rat
manufacturer/tradename
Chemicon®
technique(s)
immunoprecipitation (IP): suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... GABRA1(2554)
Immunogen
Epitope: cytoplasmic loop
Fusion protein from the cytoplasmic loop of rat GABAA receptor alpha1 subunit.
Application
Anti-GABA A Receptor α1 Antibody, cytoplasmic loop is an antibody against GABA A Receptor α1 for use in IP & WB.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurotransmitters & Receptors
Neurotransmitters & Receptors
Western blot: 1:1,000
Immunopreciptation: The antibody will immunoprecipitate 59% of all GABA A receptors in dodecysulfate extracts of rat forebrains (150 μL) using 15 μg of antibody.
Optimal working dilutions must be determined by the end user.
Immunopreciptation: The antibody will immunoprecipitate 59% of all GABA A receptors in dodecysulfate extracts of rat forebrains (150 μL) using 15 μg of antibody.
Optimal working dilutions must be determined by the end user.
Biochem/physiol Actions
GABAA receptor alpha1 subunit, cytoplasmic loop. The apparent molecular mass of 51 kDa in rat brain membrane fractions. The antibody shows no reactivity in the forebrain of alpha1 knockout mice by Western blot.
Physical form
Affinity purified immunoglobulin. Liquid in 10 mM Hepes, pH 7.5, with 150 mM NaCl, 100 μg/mL BSA and 50% glycerol. Approximate concentration is 0.15 mg/mL.
Preparation Note
Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self-defrosting freezer.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Certificates of Analysis (COA)
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Stephanie M Miller et al.
Journal of neurochemistry, 139(3), 471-484 (2016-10-25)
Seizures are a common manifestation of hypoxic-ischaemic brain injury in the neonate. In status epilepticus models alterations to GABAA R subunit expression have been suggested to contribute to (i) abnormal development of the GABAergic system, (ii) why seizures become self-sustaining
Stephanie M Miller et al.
Developmental neuroscience, 39(5), 375-385 (2017-05-05)
GABA is a major neurotransmitter in the mammalian brain. In the mature brain GABA exerts inhibitory actions via the GABAA receptor (GABAAR); however, in the immature brain GABA provides much of the excitatory drive. We examined the expression of 3
Stephanie M Miller et al.
Brain structure & function, 223(2), 1025-1033 (2017-12-29)
The GABAA receptor provides the majority of inhibitory neurotransmission in the adult central nervous system but in immature brain is responsible for much of the excitatory drive, a requirement for normal brain development. It is well established that GABAA receptor
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