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Merck

AB5668P

Anti-Neurite Outgrowth Inhibitor B Antibody

Chemicon®, from rabbit

Synonym(s):

Nogo-B

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

Key Documents

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Product Name

Anti-Neurite Outgrowth Inhibitor B Antibody, Chemicon®, from rabbit

biological source

rabbit

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rat, human, mouse

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable
western blot: suitable

NCBI accession no.

NM_007008.2
NM_020532.4
NM_153828.2
NM_207520.1
NM_207521.1

UniProt accession no.

Q9NQC3

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... RTN4(57142)

Application

Research Category
Neuroscience
Research Sub Category
Neurochemistry & Neurotrophins

Growth Cones & Axon Guidance
This Anti-Neurite Outgrowth Inhibitor B Antibody is validated for use in ELISA, WB for the detection of Neurite Outgrowth Inhibitor B.
Western blot: 1-10 μg/mL using ECL. Nogo-B has a molecular weight of approximately 37 kDa (Chen et al. 2000; GrandPre et al. 2000; Goldberg & Barres 2000; Prinijha et al. 2000; Tessier-Lavigne & Goodman 2000; Nagase et al. 1998).

Immunohistochemistry: not tested. It is recommended that the antibody be tried at 2-20 μg/mL on paraformaldehyde fixed tissue.

ELISA: 1:10,000-1:100,000 using 50-100 ng control peptide per well.

Optimal working dilutions must be determined by the end user.

Biochem/physiol Actions

Recognizes rat Neurite Outgrowth Inhibitor Protein B (Nogo-B). The immunogen sequence is present only in Nogo-B and absent in Nogo-C.

SPECIES REACTIVITIES: The immunogen peptide is 83% conserved in human Nogo-B/Foocen-m/foocen-m2. Reactivity with other species has not been confirmed.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

A 12 amino acid peptide sequence within the N-terminus and at the splice site of Nogo-A from the putative extracellular domain of rat Nogo-B (Chen et al. 2000; GrandPre et al. 2000; Goldberg & Barres 2000; Prinijha et al. 2000; Tessier-Lavigne & Goodman 2000; Nagase et al. 1998).

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Affinity purified immunoglobulin. Liquid in PBS, containing 0.1% BSA and 0.05% sodium azide.

Preparation Note

Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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