AB5757

Anti-Presenilin 1 Antibody

Name: Anti-Presenilin 1 Antibody
Brand: MM

Chemicon^®, from chicken

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About This Item

UNSPSC Code:

12352203

eCl@ss:

32160702

NACRES:

NA.41

biological source

chicken

Quality Level

100

conjugate

unconjugated

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human, mouse, rat

manufacturer/tradename

Chemicon^®

technique(s)

ELISA: suitable
western blot: suitable

NCBI accession no.

NM_000021.2

UniProt accession no.

P49768

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... PSEN1(5663)

Immunogen

Synthetic peptides from human Presenilin 1.

Application

Detect Presenilin 1 using this Anti-Presenilin 1 Antibody validated for use in ELISA & WB.

Immunoblotting: 1:1,000-1:4,000. To minimize background staining it is suggested that you include a higher content of detergent (Tween-20) in your dilution and washing solutions.

Immunohistochemistry: not tested. It is recommended that you try the antibody at 1:50-1:500.

ELISA: 1:1,000-1:4,000

Optimal working dilutions must be determined by the end user.

Research Category
Neuroscience

Research Sub Category
Neurodegenerative Diseases

Biochem/physiol Actions

Presenilin 1

Physical form

Affinity purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide.

Preparation Note

Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Early Growth Response 1 (Egr-1) Is a Transcriptional Activator of β-Secretase 1 (BACE-1) in the Brain.

Xike Qin et al.

The Journal of biological chemistry, 291(42), 22276-22287 (2016-09-01)

Accumulation of amyloid-β peptide (Aβ) in the brain is regarded as central to Alzheimer's disease (AD) pathogenesis. Aβ is generated by a sequential cleavage of amyloid precursor protein (APP) by β-secretase 1 (BACE-1) followed by γ-secretase. BACE-1 cleavage of APP

Global Trade Item Number

SKU	GTIN
AB5757	04053252668982

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