AB6046

Anti-Cytoplasmic FMR1-interacting protein 1 Antibody

Name: Anti-Cytoplasmic FMR1-interacting protein 1 Antibody
Brand: MM

from rabbit, purified by affinity chromatography

Synonym(s):

cytoplasmic FMR1 interacting protein 1, Specifically Rac1-associated protein 1, cytoplasmic FMRP interacting protein 1, cytoplasmic FMR1-interacting protein 1, selective hybridizing clone

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All Photos(3)

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Product Name

Anti-Cytoplasmic FMR1-interacting protein 1 Antibody, from rabbit, purified by affinity chromatography

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

mouse, human

species reactivity (predicted by homology)

bovine (based on 100% sequence homology), rat (based on 100% sequence homology), primate (based on 100% sequence homology), rhesus macaque (based on 100% sequence homology)

technique(s)

immunocytochemistry: suitable
western blot: suitable

UniProt accession no.

Q7L576

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... SRA1(10011)

Analysis Note

Control
HeLa cell lysate

Evaluated by Western Blot in HeLa cell lysate.
Western Blot Analysis: 1 µg/mL of the antibody detected Cytoplasmic FMR1-interacting protein 1 on 10 µg of HeLa cell lysate.

Application

Detect Cytoplasmic FMR1-interacting protein 1 using this Anti-Cytoplasmic FMR1-interacting protein 1 Antibody validated for use in WB & IC.

Research Category
Cell Structure

Signaling

Research Sub Category
Cytoskeletal Signaling

Western Blot (Snap i.d.) Analysis: 5 µg/mL from a previous lot detected Cytoplasmic FMR1-interacting protein 1 in 10 µg of HeLa cell lysate.
Immunocytochemistry Analysis: 1:500 dilution from a previous lot detected Cytoplasmic FMR1-interacting protein 1 in NIH/3T3, HeLa, and A431 cells.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Cytoplasmic FMR1-interacting protein 1 (CYFIP1) is a member of the CYFIP family. It is a component of the CYFIP1-EIF4E-FMR1 complex, a regulatory complex for translational repression that binds to the mRNA cap. Within the complex, CYFIP1 serves as an adapter between the other two components and upregulates the translation repression activity of FMR1. It regulates epithelial morphogenesis, binds F-actin, and is a component in the development and formation of axon outgrowth, lamellipodia, protrusions, and membrane ruffles. Through its interaction with RAC1, CYFIP1 regulates the activity of WASP family members. CYFIP1 is associated with Prader-Willi/Angelman syndromes and may also have a role in autism.

~ 154 kDa observed. There are three noted isoforms with calculated MWs of 51 kDa, 94 kDa, and 145 kDa Additional isoforms may be observed in some lysates.

Immunogen

Epitope: Unknown

KLH-conjugated linear peptide corresponding to an internal sequence (a.a.519-532) of human Cytoplasmic FMR1-interacting protein 1.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Development and Characterisation of an in vitro Model of Wallerian Degeneration.

Heba Elsayed et al.

Frontiers in bioengineering and biotechnology, 8, 784-784 (2020-08-06)

Following peripheral nerve injury, a sequence of events termed Wallerian degeneration (WD) takes place at the distal stump in order to allow the regenerating axons to grow back toward the target organs. Schwann cells (SCs) play a lead role in

Transcriptional Dependencies in Diffuse Intrinsic Pontine Glioma.

Surya Nagaraja et al.

Cancer cell, 31(5), 635-652 (2017-04-25)

Diffuse intrinsic pontine glioma (DIPG) is a fatal pediatric cancer with limited therapeutic options. The majority of cases of DIPG exhibit a mutation in histone-3 (H3K27M) that results in oncogenic transcriptional aberrancies. We show here that DIPG is vulnerable to

Dietary Fructose Enhances the Ability of Low Concentrations of Angiotensin II to Stimulate Proximal Tubule Na⁺ Reabsorption.

Agustin Gonzalez-Vicente et al.

Nutrients, 9(8) (2017-08-17)

Fructose-enriched diets cause salt-sensitive hypertension. Proximal tubules (PTs) reabsorb 70% of the water and salt filtered through the glomerulus. Angiotensin II (Ang II) regulates this process. Normally, dietary salt reduces Ang II allowing the kidney to excrete more salt, thereby

Anthracycline-containing chemotherapy causes long-term impairment of mitochondrial respiration and increased reactive oxygen species release in skeletal muscle.

Gilles Gouspillou et al.

Scientific reports, 5, 8717-8717 (2015-03-04)

Anticancer treatments for childhood acute lymphoblastic leukaemia (ALL) are highly effective but are now implicated in causing impaired muscle function in long-term survivors. However, no comprehensive assessment of skeletal muscle mitochondrial functions in long-term survivors has been performed and the

Cell-autonomous reduction of CYFIP2 is insufficient to induce Alzheimer's disease-like pathologies in the hippocampal CA1 pyramidal neurons of aged mice.

Ruiying Ma et al.

Animal cells and systems, 27(1), 93-101 (2023-04-01)

Cytoplasmic FMR1-interacting protein 2 (CYFIP2) is an evolutionarily conserved multifunctional protein that regulates the neuronal actin cytoskeleton, mRNA translation and transport, and mitochondrial morphology and function. Supporting its critical roles in proper neuronal development and function, human genetic studies have

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Global Trade Item Number

SKU	GTIN
AB6046	04053252747663

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