Anti-Tenomodulin/TNMD Antibody

Tenomodulin (TNMD) is a transmembrane glycoprotein that was original discovered as being predominantly expressed in tendons, ligaments, and eyes, whereas the only other family member, chondromodulin I (ChM-I), is highly expressed in cartilage and at lower levels in the eye and thymus. The C-terminal extracellular domain of TNMD has been shown to modulate endothelial-cell proliferation and tube formation thus also suggesting a role in angiogenesis, perhaps as an angiogenesis inhibitor like its other family member chondromodulin I. TNMD knockouts show a decrease in tendon density and the collagen fibrils present in the tendons are enlarged and highly variable in diameter. Thus TNMD is thought to also be important in tenocyte proliferation and in collagen fibril maturation. Genetic variation in TNMD is associated with a risk for type 2 diabetes, central obesity, and serum levels of systemic immune mediators in a body size-dependent manner suggesting a role in metabolism as well. Finally, TNMD is also a suspected gene of age-related macular degeneration disorder.

~45 kDa observed band is the glycosylated full-length Tenomodulin/TNMD protein. ~37 kDa calculated band is the unglycosylated Tenomodulin/TNMD protein. Other uncharacterized bands may be detected.

Epitope: C-terminus

KLH-conjugated linear peptide corresponding to the C-terminus of Human Tenomodulin/TNMD.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

This Anti-Tenomodulin/TNMD Antibody is validated for use in Western Blotting and Immunohistochemistry for the detection of Tenomodulin/TNMD.

Western Blotting Analysis: 1 µg/mL from a representative lot detected Tenomodulin/TNMD in 10 µg of human skeletal muscle tissue lysate.

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Tenomodulin/TNMD in myocytes of human cardiac tissue and human skeletal muscle tissue.

Antigen Affinity Purified

Purified rabbit Polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Evaluated by Western Blotting in Mouse eye tissue lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected Tenomodulin/TNMD in 10 µg of Mouse eye tissue lysate.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.