ABC445

Anti-GHRHR Antibody

Name: Anti-GHRHR Antibody
Brand: MM

from rabbit, purified by affinity chromatography

Synonym(s):

Growth hormone-releasing hormone receptor, GHRH receptor, Growth hormone-releasing factor receptor, GRF receptor, GRFR

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About This Item

UNSPSC Code:

12352203

eCl@ss:

32160702

NACRES:

NA.41

biological source

rabbit

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human, rat

technique(s)

immunohistochemistry: suitable (paraffin)
western blot: suitable

NCBI accession no.

NP_000814

UniProt accession no.

Q02643

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... GHRHR(2692)

General description

GHRHR is the receptor for growth hormone release hormone (GRF, GHRF). GHRF is first produced between 18 and 29 weeks of gestation and is responsible for the production of growth hormone (GH), and GH is required for proper normal postnatal growth, bone growth, regulatory effects on protein, carbohydrate, and lipid metabolism. GHRHR is localized on cells particularly in the anterior pituitary and mutations in this gene have been associated with growth hormone deficiency, or Dwarfism of Sindh. GHRHR is localized on membranes, both plasma and nuclear membranes, and its translocation acts as a first step in the cellular signals leading to exocytotic GH secretion in the anterior pituitary.

~41 kDa observed. The calculated molecular weight is 47 kDa, however GHRHR has been shown as a ~41 kDa band in western blots (Zeitler, P., et al. (1998). J. Mol. Endocrinol. 21(3):363-371).

Immunogen

KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human GHRHR.

Application

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected GHRHR in rat pituitary tissue.

This Anti-GHRHR Antibody is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of GHRHR.

Analysis Note

Evaluated by Western Blotting in human brain tissue lysate.

Western Blotting Analysis: A 1:500 dilution of this antibody detected GHRHR in 10 µg of human brain tissue lysate.

Other Notes

Concentration: Please refer to lot specific datasheet.

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Storage Class Code

10 - Combustible liquids

Certificates of Analysis (COA)

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