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ABC470

Anti-Kallikrein-5 Antibody/KLK5

Name: Anti-Kallikrein-5 Antibody/KLK5
Brand: MM

from rabbit, purified by affinity chromatography

Synonym(s):

Kallikrein-5, Kallikrein-like protein 2, KLK-L2, Stratum corneum tryptic enzyme, Kallikrein-5/KLK5

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IHC, WB

Citations:

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Properties

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

mouse, human

species reactivity (predicted by homology)

gorilla (based on 100% sequence homology), chimpanzee (based on 100% sequence homology)

technique(s)

immunohistochemistry: suitable, western blot: suitable

NCBI accession no.

NP_001070959

UniProt accession no.

Q9Y337

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... KLK5(25818)

Description

General description

Kallikrein-5/KLK5, or also known as Kallikrein-related peptidase 5, Kallikrein-like protein 2, KLK-L2, and formerly known as Stratum corneum tryptic enzyme (SCTE), is an important enzyme encoded by the gene KLK5/KLK-L2/SCTE. KLK5 is a secreted serine protease enzyme that is expressed in many tissues including the skin, breast and brain. In the skin, Kallikreins-related peptidases (KLKs) are proteases that are important for the desquamation process of the skin (cell shedding). KLK5 is considered as one of the most important KLKs in skin desquamation because KLK5 also regulates the activation of other Kallikreins needed for cell shedding. In disease, KLK5 displays aberrant expression in many cancers. However, expression of KLK5 in some cancer cells appears to suppress tumor growth and activity via reduced RhoA activity and the modulation the mevalonate pathway. This is particularly true in breast cancer and efforts are examining methods to increase KLK5 expression in breast cancer as a form of treatment.

~32 kDa observed

Immunogen

KLH-conjugated linear peptide corresponding to the Peptidase S1 domain of human Kallikrein-5/KLK5.

Application

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Kallikrein-5/KLK5 in human skin cancer sections tissue.

This Anti-Kallikrein-5 Antibody/KLK5 is validated for use in Western Blotting and Immunohistochemistry for the detection of Kallikrein-5/KLK5.

Analysis Note

Evaluated by Western Blotting in ovcar 3 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Kallikrein-5/KLK5 in 10 µg of ovcar 3 cell lysate.

Other Notes

Concentration: Please refer to lot specific datasheet.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c