Anti-ARC Antibody

ARC (also known as Nucleolar protein 3, Apoptosis repressor with CARD, Muscle-enriched cytoplasmic protein, Myp, Nucleolar protein of 30 kDa, Nop30, NOL3, and NOP) is a novel apoptosis repressor. ARC interacts with caspase-2 and –8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1, and DR3. The messenger RNA of ARC is primarily expressed in skeletal muscle and cardiac tissue.

~24 kDa observed. Uncharacterized bands may be observed in some lysate(s).

Epitope: N-terminus

KLH-conjugated linear peptide corresponding to amino acids 2-18 of the N-terminus of human ARC.

Anti-ARC Antibody is a highly specific rabbit polyclonal antibody, that targets ARC & has been tested in western blotting.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

This antibody was raised against a peptide corresponding to amino acids 2 to 18 of human ARC. This sequence is identical to human nuclear protein Nop30 and differ from the rat homolog of ARC by one amino acid.

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Evaluated by Western Blotting in HeLa whole cell lysate.

Western Blotting Analysis: A 1:500 dilution of this antibody detected ARC in HeLa whole cell lysate.

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.