Anti-Syntaxin 17 Antibody

Syntaxin-17 (UniProt P56962) is encoded by the STX17 gene (Gene ID 55014) in human. Syntaxin-17 belongs to the Soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein receptor (SNARE) family of proteins that mediate membrane fusion events. Syntaxin-17 functions as the autophagosomal Qa-SNARE required for autophagosome-lysosome fusion and it mediates the fusion process by binding to its partner SNAREs, synaptosomal-associated protein 29 (SNAP29; Qbc-SNARE), and vesicle-associated membrane protein 8 (VAMP8; R-SNARE). In addition, the homotypic fusion and protein sorting (HOPS) complex is reported to interact with Syntaxin-17 and promotes Syntaxin-17-dependent autophagosome-lysosome fusion.

~38 kDa observed. Uncharacterized band(s) may appear in some lysates.

Epitope: cytoplasmic domain

KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human Syntaxin 17.

Immunohistochemistry Analysis: A 1:50-250 dilution from a representative lot detected Syntaxin 17 in human kidney and human adrenal gland tissue.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

This Anti-Syntaxin 17 Antibody is validated for use in Western Blotting, Immunohistochemistry for the detection of Syntaxin 17.

Affinity purified

Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Evaluated by Western Blotting in human adrenal tissue lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected Syntaxin 17 in 10 µg of human adrenal tissue lysate.

Concentration: Please refer to lot specific datasheet.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.