Anti-Pygo1 Antibody

Wnt/Wingless signaling controls many fundamental processeses, such as cellular growth and fate, and is known to be involved in embryonic segmentation, limb development and CNS patterning. Wnt signaling is also shown to influence postembryonic regulation of stem cell numbers and stem cell differentiation in epithelia, such as those of the colon and skin.
Wnt transduction is mediated by the association of Beta-Catenin with nuclear TCF DNA binding factors, including legless (lgs) and pygopus (pygo). Whereas lgs enclodes BCL9, pygo encodes a Pygopus (Pygo), a PHD finger protein. It is reported that BCL9 acts as an adaptor protein that recruits and physically links Pygo to the Beta-Catenin-TCF Complex. It is demonstrated that the recruitment of Pygo is required for this respective complex to function as a transcriptional co-activator of specific target genes.

~49 kDa observed

KLH-conjugated linear peptide corresponding to human Pygopus homolog 1.

Anti-Pygo1 Antibody is a Rabbit Polyclonal Antibody for detection of Pygo1 also known as Pygopus homolog 1 & has been validated in WB.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Developmental Signaling

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Control
Human placenta tissue lysate.

Evaluated by Western Blot in human placenta tissue lysate.

Western Blot Analysis: 0.1 µg/mL of this antibody detected Pygo1 in human placenta tissue lysate.

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.