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Key Documents

ABE211

Sigma-Aldrich

Anti-CFP1 Antibody

serum, from rabbit

Synonym(s):

CXXC finger 1 (PHD domain), PHD finger and CXXC domain-containing protein 1, CXXC-type zinc finger protein 1, cpG-binding protein, CpG binding protein, zinc finger, CpG binding-type containing 1, DNA-binding protein with PHD finger and CXXC domain

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, rat

technique(s)

western blot: suitable

NCBI accession no.

NP_055408

UniProt accession no.

Q9P0U4

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... CXXC1(30827)

General description

CXXC finger protein 1 (CFP1) is part of the Setd1A and Setd1B methyltransferase compounds. Research shows that CFP1 also interacts with the cytosine methylation mechanism. CFP1 is necessary for development of mammals and is a key regulator of chromatin structure. Embryonic stem cells that are missing CFP1 are more susceptible to DNA-damaging agents and tend to build up more DNA damage. CFP1 has been shown to also be a regulator of DNA repair.
~78 kDa observed. A cross-reacting band observed at ~110 kDa

Immunogen

GST-tagged recombinant protein corresponding to human CFP1.

Application

Use Anti-CFP1 Antibody (Rabbit Polyclonal Antibody) validated in WB to detect CFP1 also known as CXXC finger 1 (PHD domain), cpG-binding protein.

Analysis Note

Evaluated by Western Blot in HeLa nuclear extract.

Western Blot Analysis: 1:1,000 dilution of this antibody detected CFP1 on 10 µg of HeLa nuclear extract.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Certificates of Analysis (COA)

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Kevin R Costello et al.
eLife, 10 (2021-10-21)
Transposable elements (TEs) are mobile genetic elements that make up a large fraction of mammalian genomes. While select TEs have been co-opted in host genomes to have function, the majority of these elements are epigenetically silenced by DNA methylation in
Yukiko Imai et al.
Chromosoma, 126(6), 681-695 (2017-05-21)
PR domain-containing protein 9 (PRDM9) is a major regulator of the localization of meiotic recombination hotspots in the human and mouse genomes. This role involves its DNA-binding domain, which is composed of a tandem array of zinc fingers, and PRDM9-dependent
Yu-Ling Lee et al.
eLife, 4, e06283-e06283 (2015-06-13)
MAF1 represses Pol III-mediated transcription by interfering with TFIIIB and Pol III. Herein, we found that MAF1 knockdown induced CDKN1A transcription and chromatin looping concurrently with Pol III recruitment. Simultaneous knockdown of MAF1 with Pol III or BRF1 (subunit of

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