ABE234
Anti-Friend of PRMT1 Antibody
serum, from rabbit
Synonym(s):
Chromatin target of PRMT1 protein, Friend of PRMT1 protein, Small arginine- and glycine-rich protein, SRAG, Chromatin target of PRMT1, Friend-of Prmt1, Chtop, FOP
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ChIP, WB
Citations:
-
biological source
rabbit
Quality Segment
conjugate
unconjugated
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human, rat, mouse
technique(s)
ChIP: suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... CHTOP(26097)
mouse ... CHTOP(66511)
rat ... CHTOP(361990)
General description
The protein called Friend of PRMT1 (FOP), or more correctly Chromatin target of PRMT1 protein, or Small arginine and glycine rich protein (SRAG) is an important partner in estrogen receptor gene activation events and plays a role in 5FMC mediated desumoylation of ZNF148 and the subsequent gene activations of its target genes. Friend of PRMT1 also interacts with other methyltransferases such as PRMT5. The protein is also a component of the dynamic TREX mRNA export complex where it assists in mRNA export. The protein is expressed in the nucleus and contained in the nucleolus of various cell types including erythroid progenitor cells.
~32 kDa observed
Immunogen
Epitope: C-terminus
GST-tagged recombinant protein corresponding to the C-terminus of human Friend of PRMT1.
Application
Anti-Friend of PRMT1 Antibody is an antibody against Friend of PRMT1 for use in western blotting & ChIP.
Chromatin Immunoprecipitation Analysis: A representative lot from an independent laboratory detected Friend of PRMT1 in MCF-7 cell lysate (Van Dijk, T. B., et al. (2010). Mol Cell Biol. 30(1):260-272.).
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Chromatin Biology
Chromatin Biology
Physical form
Rabbit polyclonal serum with 0.05% sodium azide.
Unpurified
Preparation Note
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Analysis Note
Evaluated by Western Blotting in A431 cell lysate.
Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected Friend of PRMT1 in 10 µg of A431 cell lysate.
Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected Friend of PRMT1 in 10 µg of A431 cell lysate.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
Certificates of Analysis (COA)
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