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Key Documents

ABF217

Sigma-Aldrich

Anti-LGP2 Antibody

from rabbit, purified by affinity chromatography

Synonym(s):

Probable ATP-dependent RNA helicase DHX58, Probable ATP-dependent helicase LGP2, Protein D11Lgp2 homolog, RIG-I-like receptor 3, RLR-3, RIG-I-like receptor LGP2, RLR

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rat

species reactivity (predicted by homology)

human (immunogen homology)

technique(s)

western blot: suitable

UniProt accession no.

Q96C10

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... DHX58(79132)

General description

Probable ATP-dependent RNA helicase DHX58 (LGP2), also known as RIG-I-like receptor 3 (RLR-3), is a member of the helicase family (RLR subfamily). LGP2 acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. It cannot initiate antiviral signaling since it does not contain the CARD domain required for activating MAVS/IPS1-dependent signaling events.
~62 kDa observed

Immunogen

Epitope: C-terminus
KLH-conjugated linear peptide corresponding to the C-terminus of human LGP2.

Application

Detect Probable ATP-dependent RNA helicase DHX58 using this rabbit polyclonal antibody, Anti-LGP2 Antibody validated for use in western blotting.
Research Category
Inflammation & Immunology
Research Sub Category
Immunoglobulins & Immunology

Biochem/physiol Actions

This antibody recognizes the C-terminus of LGP2.

Physical form

Antigen Affinity Purified
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Rat kidney tissue lysate
Evaluated by Western Blotting in rat kidney tissue lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected LGP2 in 15 µg of rat kidney tissue lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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