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Key Documents

ABF289

Sigma-Aldrich

Anti-PPAPDC2 Antibody

from rabbit, purified by affinity chromatography

Synonym(s):

Presqualene diphosphate phosphatase, Phosphatidic acid phosphatase type 2 domain-containing protein 2, PPAP2 domain-containing protein 2

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human

technique(s)

western blot: suitable

UniProt accession no.

Q8IY26

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... PPAPDC2(403313)

General description

Presqualene diphosphate phosphatase, also known as Phosphatidic acid phosphatase type 2 domain-containing protein 2 (PPAP2 domain-containing protein 2), and encoded by the gene name PPAPDC2, is a phosphatase that dephosphorylates Presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may have important role in innate immunity. PSDP is a bioactive lipid that rapidly remodels to PSMP upon cell activation. PPAPDC2 displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid. PPAPDC2 activity is independent of Mg2+ and has been identified in activated human neutrophil (PMN) extracts. It is widely expressed, particularly in gastronintestinal organs, spleen, placenta, kidney, thymus, and brain. Recent studies show PPAPDC2 is a functional isoprenoid diphosphate phosphatase.
~42 kDa observed

Immunogen

KLH-conjugated synthetic peptide corresponding to the C-terminus of human PPAPDC2.

Application

Anti-PPAPDC2 Antibody detects level of PPAPDC2 & has been published & validated for use in PPAPDC2.

Analysis Note

Evaluated by Western Blotting in Raji cell lysate with and without blocking peptide.

Western Blotting Analysis: 1 μg/mL of this antibody detected PPAPDC2 in Raji cell lysate with and without blocking peptide.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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