ABF289
Anti-PPAPDC2 Antibody
from rabbit, purified by affinity chromatography
Synonym(s):
Presqualene diphosphate phosphatase, Phosphatidic acid phosphatase type 2 domain-containing protein 2, PPAP2 domain-containing protein 2
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human
technique(s)
western blot: suitable
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... PPAPDC2(403313)
General description
Presqualene diphosphate phosphatase, also known as Phosphatidic acid phosphatase type 2 domain-containing protein 2 (PPAP2 domain-containing protein 2), and encoded by the gene name PPAPDC2, is a phosphatase that dephosphorylates Presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may have important role in innate immunity. PSDP is a bioactive lipid that rapidly remodels to PSMP upon cell activation. PPAPDC2 displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid. PPAPDC2 activity is independent of Mg2+ and has been identified in activated human neutrophil (PMN) extracts. It is widely expressed, particularly in gastronintestinal organs, spleen, placenta, kidney, thymus, and brain. Recent studies show PPAPDC2 is a functional isoprenoid diphosphate phosphatase.
~42 kDa observed
Immunogen
KLH-conjugated synthetic peptide corresponding to the C-terminus of human PPAPDC2.
Application
Anti-PPAPDC2 Antibody detects level of PPAPDC2 & has been published & validated for use in PPAPDC2.
Analysis Note
Evaluated by Western Blotting in Raji cell lysate with and without blocking peptide.
Western Blotting Analysis: 1 μg/mL of this antibody detected PPAPDC2 in Raji cell lysate with and without blocking peptide.
Western Blotting Analysis: 1 μg/mL of this antibody detected PPAPDC2 in Raji cell lysate with and without blocking peptide.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Storage Class
12 - Non Combustible Liquids
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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