Anti-Aspa/Nur7 Antibody

Target molecular weight ~ 37 kDa observed. 35.35 kDa kDa calculated. Uncharacterized bands may be observed in some lysate(s).

Aspartoacylase (EC 3.5.1.15; UniProt Q8R3P0; also known as Acy-2, Aminoacylase-2, Nur-7) is encoded by the Aspa (also known as Acy2) gene (Gene ID 11484) in murine species. Aspartoacylase catalyzes the deacetylation of N-acetylaspartate (NAA) to generate free acetate in the central nervous system (CNS). Mutations in the ASPA gene cause the autosomal recessive neurodegenerative Canavan disease (CD) that results in inadequate lipid/myelin synthesis during development. Immunohistochemical staining reveals that aspartoacylase colocalizes with the oligodendrocyte marker CC1 throughout the brain, indicating its role in myelination.

Full-length, mouse recombinant Aspa/Nur7 protein.

Tested applications


Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected Aspa/Nur7 in human brain and mouse brain tissue lysates.

Immunohistochemistry (Paraffin) Analysis: A 1:500 dilution from a representative lot detected Aspa/Nur7 in mouse and rat brain tissue sections.

Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user.

This rabbit polyclonal, Cat. No. ABN1698, detects Aspa/Nur7.

Research Category
Neuroscience

Research Sub Category
Developmental Signaling

Protein G Purified

Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Recommended storage: +2°C to +8°C.

Evaluated by Western Blotting in rat brain tissue lysate.

Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Aspartoacylase in rat brain tissue lysate.

Concentration: Please refer to lot specific datasheet.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.