ABN259

Anti-PANK2 Antibody

Name: Anti-PANK2 Antibody
Brand: MM

from rabbit, purified by affinity chromatography

Synonym(s):

Pantothenate kinase 2, mitochondrial, hPanK2, Pantothenic acid kinase 2

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About This Item

UNSPSC Code:

12352203

eCl@ss:

32160702

NACRES:

NA.41

biological source

rabbit

Quality Level

300

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human

technique(s)

western blot: suitable

NCBI accession no.

NP_705902

UniProt accession no.

Q9BZ23

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... PANK2(80025)

General description

PANK2 (Pantothenate kinase 2) phosphorylates pantothenic acid (vitamin B(5) and regulates the overall rate of coenzyme A (CoA) biosynthesis. PANK2 thereby plays an important role in lipid metabolism and energy production. Mutation or knockdown of the PANK2 gene results in various disease states, including hypoglycemia, hyperketonemia, faulty metabolism, poor postnatal development, and childhood neurodegeneration.

~62/37 kDa observed. Uncharacterized bands may appear at ~15 kDa, ~25 kDa, and ~260 kDa in some lysates. The calculated molecular weight is 62 kDa, however PANK2 has been shown as a ~40 kDa band in western blots (Kotzbauer, P. T., et al. (2005). The Journal of Neuroscience. 25(3):689-698).

Immunogen

KLH-conjugated linear peptide corresponding to human PANK2.

Application

Detect the PANK2 protein using this Anti-PANK2 validated for use in WB.

Biochem/physiol Actions

This antibody demonstrates specificity for isoform 1, but does not cross react with other isoforms.

Analysis Note

Evaluated by Western Blot in human hippocampus tissue lysate.

Western Blot Analysis: 1.0 µg/mL of this antibody detected PANK2 in 10 µg of human hippocampus tissue lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class Code

10 - Combustible liquids

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Global Trade Item Number

SKU	GTIN
ABN259	04053252847691

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