Key Documents

COA/COQ

ABN408

Anti-MPRIP Antibody

Name: Anti-MPRIP Antibody
Brand: MM

from rabbit, purified by affinity chromatography

Synonym(s):

Myosin phosphatase Rho-interacting protein, M-RIP, Rho-interacting protein 3, RIP3, p116Rip

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About This Item

UNSPSC Code:

12352203

eCl@ss:

32160702

NACRES:

NA.41

biological source

rabbit

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rat, human

species reactivity (predicted by homology)

chimpanzee (based on 100% sequence homology), canine (based on 100% sequence homology), ferret (based on 100% sequence homology), gorilla (based on 100% sequence homology), giant panda (based on 100% sequence homology), feline (based on 100% sequence homology)

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NP_055949

UniProt accession no.

Q6WCQ1

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... MPRIP(23164)

General description

MPRIP, also known as Myosin phosphatase Rho-interacting protein, M-RIP, Rho-interacting protein 3, RIP3, or p116Rip, and encoded by the gene MPRIP/KIAA0864/MRIP/RHOIP3, is an important regulator or actin cytoskeleton interactions. In muscle and neurons MPRIP targets myosin phosphatase to the actin cytoskeleton and its interaction with phosphorylated myosin. Overexpression of MPRIP leads to disassembly of actin stress fibers in neuronal and other cells types. MPRIP though its interaction with the actin cytoskeleton modulates cell morphology, particularly in neurons and strongly structural cell types, and MPRIP appears to play a key role in the JNK signaling cascade and in cell motility in invasive cancer cells, thus MPRIP is a current target for anti-cancer therapy. MPRIP interacts with RHOA, ROCK, MYZAP, Syntenin-1 and other cell structure associated proteins. MPRIP co-localizes with F-actin in most cells, and thus it is largely cytoplasmically localized.

~135 kDa observed

Immunogen

KLH-conjugated linear peptide corresponding to human MPRIP.

Application

Anti-MPRIP Antibody detects level of MPRIP & has been published & validated for use in MPRIP.

Immunohistochemistry Analysis: A 1:50-500 dilution from a representative lot detected MPRIP in human stomach and human cerebellum tissue.

Analysis Note

Evaluated by Western Blotting in SH-SY5Y cell lysate.

Western Blotting Analysis: 3.0 µg/mL of this antibody detected MPRIP in 10 µg of SH-SY5Y cell lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)