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Key Documents

ABN999

Sigma-Aldrich

Anti-Gustducin alpha-3 chain

Synonym(s):

Gustducin alpha-3 chain|Guanine nucleotide-binding protein G(t) subunit alpha-3

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

clone

polyclonal

species reactivity

human, rat

technique(s)

immunohistochemistry: suitable
western blot: suitable

General description

Gustducin alpha-3 chain is a G protein alpha subunit of the taste receptors and it plays a critical role in bitter, sweet and umami (MSG) taste transduction. Gustducin alpha-3 chain operates via the cGMP-phosphodiesterase signaling pathway and is mediated with calcium. Gustducin alpha-3 chain also functions in lumenal sugar sensors in the gut and may modulate the gut capacity to absorb sugars and thus play roles in malabsorption syndromes and diet related disorders including diabetes type II and obesity. Gustducin alpha-3 chain is localized to the cytoplasm and plasmalemmal being a G protein subunit. Gustducin alpha-3 chain is expressed in tastebuds and in the gut in enteroendocrine L cells, and surprisingly in spermatozoa.

Immunogen

KLH-conjugated linear peptide corresponding to human Gustducin alpha-3 chain near the C-terminal.

Application

Anti-Gustducin alpha-3 chain Antibody is an antibody against Gustducin alpha-3 chain for use in Immunohistochemistry and Immunocytochemistry.
Immunohistochemistry Analysis: A 1:50-250 dilution from a representative lot detected Gustducin alpha-3 chain in human ileum and rat testis tissue.

Analysis Note

Evaluated by Western Blotting in human tongue tissue lysate.

Western Blotting Analysis: 0.5 ug/mL of this antibody detected Gustducin alpha-3 chain in 10 ug of human tongue tissue lysate.

Other Notes

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial

Certificates of Analysis (COA)

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Global Trade Item Number

SKUGTIN
ABN99904055977135275

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