ABS22

Anti-PDE4D Antibody

Name: Anti-PDE4D Antibody
Brand: MM

from rabbit

Synonym(s):

phosphodiesterase 4D, cAMP-specific, cAMP-specific phosphodiesterase PDE4D6, cAMP-specific 3′,5′-cyclic phosphodiesterase 4D, phosphodiesterase 4D, cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E3), phosphodiesterase 4D, cAMP-specific (dunc

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About This Item

UNSPSC Code:

12352203

eCl@ss:

32160702

NACRES:

NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

purified antibody

clone

polyclonal

species reactivity

rat, human

species reactivity (predicted by homology)

chimpanzee (based on 100% sequence homology), mouse (based on 90% sequence homology)

technique(s)

western blot: suitable

NCBI accession no.

NP_001098101

UniProt accession no.

Q08499

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... PDE4D(5144)

General description

Phosphodiesterase 4D (PDE4D) is a member of the PDE cyclic nucleotides. PDE4D is known to be regulated by protein kinase C (PKC)-Raf-MEK-ERK and also by cAMP in vascular smooth muscle cells. PDE4D is essential to have equilibrium in relaxing and contracting cues to airway smooth muscle. Down-regulation of PDE4D may be associated with analgesic and anti-inflammatory effects. It has also been linked to the risk of stroke, specifically common polygenic stroke.

~ 59, 68, 85, 90, and 105 kDa observed. UniProtKB/Swiss-Prot Q08499 (PDE4D_HUMAN) entry describes 12 isoforms produced by alternative splicing: Isoform 1 at 91.115 kDa, Isoform 2 at 76.369 kDa, Isoform 3 at 68.607 kDa, Isoform 4 at 66.376 kDa, Isoform 5 at 57.792 kDa, Isoform 6 at 84.428 kDa, Isoform 7 at 23.839 kDa, Isoform 8 at 59.113 kDa, Isoform 9 at 77.705 kDa, Isoform 10 at 76.816 kDa, Isoform 11 at 84.662 kDa, and Isoform 12 at 24.429 kDa

Immunogen

GST-tagged recombinant protein corresponding to the C-terminus of human PDE4D.

Application

Anti-PDE4D Antibody is an antibody against PDE4D for use in WB.

Biochem/physiol Actions

This antibody recognizes PDE4D at the C-terminus.

Physical form

Format: Purified

Analysis Note

Evaluated by Western Blot in rat brain tissue lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected PDE4D on 10 µg of rat brain tissue lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Inhibition of phosphodiesterase 4D suppresses mTORC1 signaling and pancreatic cancer growth.

Mi-Hyeon Jeong et al.

JCI insight, 8(13) (2023-07-10)

The mammalian target of rapamycin complex 1 (mTORC1) senses multiple upstream stimuli to orchestrate anabolic and catabolic events that regulate cell growth and metabolism. Hyperactivation of mTORC1 signaling is observed in multiple human diseases; thus, pathways that suppress mTORC1 signaling

Trio Haploinsufficiency Causes Neurodevelopmental Disease-Associated Deficits.

Sara Marie Katrancha et al.

Cell reports, 26(10), 2805-2817 (2019-03-07)

Heterozygous coding mutations in TRIO are associated with neurodevelopmental disorders, including autism, schizophrenia, bipolar disorder, and epilepsy, and impair TRIO's biochemical activities. To model mutant alleles, we ablated one or both Trio alleles from excitatory neurons in the cortex and

Phosphodiesterase PDE4D Is Decreased in Frontal Cortex of Aged Rats and Positively Correlated With Working Memory Performance and Inversely Correlated With PKA Phosphorylation of Tau.

Shannon N Leslie et al.

Frontiers in aging neuroscience, 12, 576723-576723 (2020-11-17)

Age is the largest risk factor for Alzheimer's disease (AD) and contributes to cognitive impairment in otherwise healthy individuals. Thus, it is critical that we better understand the risk aging presents to vulnerable regions of the brain and carefully design

Phosphodiesterase isoform-specific expression induced by traumatic brain injury.

Anthony A Oliva et al.

Journal of neurochemistry, 123(6), 1019-1029 (2012-10-13)

Traumatic brain injury (TBI) results in significant inflammation which contributes to the evolving pathology. Previously, we have demonstrated that cyclic AMP (cAMP), a molecule involved in inflammation, is down-regulated after TBI. To determine the mechanism by which cAMP is down-regulated

Traumatic Brain Injury Upregulates Phosphodiesterase Expression in the Hippocampus.

Nicole M Wilson et al.

Frontiers in systems neuroscience, 10, 5-5 (2016-02-24)

Traumatic brain injury (TBI) results in significant impairments in hippocampal synaptic plasticity. A molecule critically involved in hippocampal synaptic plasticity, 3',5'-cyclic adenosine monophosphate, is downregulated in the hippocampus after TBI, but the mechanism that underlies this decrease is unknown. To

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Global Trade Item Number

SKU	GTIN
ABS22	04053252520143

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