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ABS22

Anti-PDE4D Antibody

Name: Anti-PDE4D Antibody
Brand: MM

from rabbit

Synonym(s):

phosphodiesterase 4D, cAMP-specific, cAMP-specific phosphodiesterase PDE4D6, cAMP-specific 3′,5′-cyclic phosphodiesterase 4D, phosphodiesterase 4D, cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E3), phosphodiesterase 4D, cAMP-specific (dunc

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Conjugate:

unconjugated

Clone:

polyclonal

Application:

Citations:

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Properties

biological source

rabbit

Quality Segment

100

conjugate

unconjugated

antibody form

purified antibody

clone

polyclonal

species reactivity

rat, human

species reactivity (predicted by homology)

chimpanzee (based on 100% sequence homology), mouse (based on 90% sequence homology)

technique(s)

western blot: suitable

NCBI accession no.

NP_001098101

UniProt accession no.

Q08499

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... PDE4D(5144)

Description

General description

Phosphodiesterase 4D (PDE4D) is a member of the PDE cyclic nucleotides. PDE4D is known to be regulated by protein kinase C (PKC)-Raf-MEK-ERK and also by cAMP in vascular smooth muscle cells. PDE4D is essential to have equilibrium in relaxing and contracting cues to airway smooth muscle. Down-regulation of PDE4D may be associated with analgesic and anti-inflammatory effects. It has also been linked to the risk of stroke, specifically common polygenic stroke.

~ 59, 68, 85, 90, and 105 kDa observed. UniProtKB/Swiss-Prot Q08499 (PDE4D_HUMAN) entry describes 12 isoforms produced by alternative splicing: Isoform 1 at 91.115 kDa, Isoform 2 at 76.369 kDa, Isoform 3 at 68.607 kDa, Isoform 4 at 66.376 kDa, Isoform 5 at 57.792 kDa, Isoform 6 at 84.428 kDa, Isoform 7 at 23.839 kDa, Isoform 8 at 59.113 kDa, Isoform 9 at 77.705 kDa, Isoform 10 at 76.816 kDa, Isoform 11 at 84.662 kDa, and Isoform 12 at 24.429 kDa

Immunogen

GST-tagged recombinant protein corresponding to the C-terminus of human PDE4D.

Application

Anti-PDE4D Antibody is an antibody against PDE4D for use in WB.

Biochem/physiol Actions

This antibody recognizes PDE4D at the C-terminus.

Physical form

Format: Purified

Analysis Note

Evaluated by Western Blot in rat brain tissue lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected PDE4D on 10 µg of rat brain tissue lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c