Key Documents

COA/COQ

ABS227

Anti-FKBP5 Antibody

Name: Anti-FKBP5 Antibody
Brand: MM

from rabbit, purified by affinity chromatography

Synonym(s):

Peptidyl-prolyl cis-trans isomerase FKBP5, Peptidyl-prolyl cis-trans isomerase FKBP5, 51 kDa FK506-binding protein, 51 kDa FKBP, FKBP-51, 54 kDa progesterone receptor-associated immunophilin, Androgen-regulated protein 6, FF1 antigen, FK506-binding prote

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All Photos(2)

About This Item

UNSPSC Code:

12352203

eCl@ss:

32160702

NACRES:

NA.41

biological source

rabbit

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

mouse, human

species reactivity (predicted by homology)

bovine (based on 100% sequence homology)

technique(s)

western blot: suitable

NCBI accession no.

NP_004108

UniProt accession no.

Q13451

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... FKBP5(2289)

General description

FK506 binding protein 51 (FKBP5) is a ubiquitous immunophilin, which has been implicated in multiple mood disorders such as depression, anxiety, and post-traumatic stress disorder, through its regulation of multiple enzymes, transcription factors, and other signaling molecules. It is also a well known co-chaperone of the Hsp90 protein, which regulates the signaling of the glucocorticoid receptor (GR), by a negative feedback mechanism. The expression of FKBP5 increases with rising glucocorticoid levels, and FKBP5 in turn decreases GR signaling by promoting nuclear translocation of GR isoforms. In contrast, FKBP5 functions as a positive regulator of the androgen receptor.

~56 kDa observed. An uncharacterized band at ~15 kDa may be observed in some cell lysates.

Immunogen

KLH-conjugated linear peptide corresponding to human FKBP5.

Application

Anti-FKBP5 Antibody is an antibody against FKBP5 for use in Western Blotting.

Western Blot Analysis: 0.05 µg/mL of this antibody detected FKBP5 in 10 mg of K562 cell lysate.

Biochem/physiol Actions

Other homologies: Rat (92% sequence homology).

Analysis Note

Evaluated by Western Blot in HEK293 cell lysate.

Western Blot Analysis: 0.05 mg/mL of this antibody detected FKBP5 in 10 mg of HEK293 cell lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Replaces: MABC654

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)