ABS402

Anti-CDKL5 NT Antibody

Name: Anti-CDKL5 NT Antibody
Brand: MM

from rabbit, purified by affinity chromatography

Synonym(s):

Cyclin-dependent kinase-like 5, CDKL5

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About This Item

UNSPSC Code:

12352203

eCl@ss:

32160702

NACRES:

NA.41

biological source

rabbit

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

mouse, rat

technique(s)

western blot: suitable

NCBI accession no.

NP_001019795

UniProt accession no.

Q3UTQ8

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

mouse ... Cdkl5(382253)

General description

Cyclin-dependent kinase-like 5 (CDKL5) is a serine/threonine-protein kinase that mediates phosphorylation of Methyl-CpG-binding protein 2 (MECP2). MECP2 is a chromosomal protein that binds to methylated DNA, specifically to a single methyl-CpG pair. MECP2 mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A.

~ 115 kDa observed

Immunogen

GST-tagged recombinant protein corresponding to mouse CDKL5 near the N-terminus.

Application

Anti-CDKL5 NT Antibody is a highly specific rabbit polyclonal antibody, that targets Cyclin-dependent kinase-like 5 & has been tested in western blotting.

Western Blotting Analysis: A representative lot detected CDKL5 in mouse brain tissue expressing wild type CDKL5 and not in mouse brain tissue expressing knockout CDKL5.

Analysis Note

Evaluated by Western Blotting in rat brain tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected CDKL5 in 10 µg of rat brain tissue lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Temporal manipulation of Cdkl5 reveals essential postdevelopmental functions and reversible CDKL5 deficiency disorder-related deficits.

Barbara Terzic et al.

The Journal of clinical investigation, 131(20) (2021-10-16)

CDKL5 deficiency disorder (CDD) is an early onset, neurodevelopmental syndrome associated with pathogenic variants in the X-linked gene encoding cyclin-dependent kinase-like 5 (CDKL5). CDKL5 has been implicated in neuronal synapse maturation, yet its postdevelopmental necessity and the reversibility of CDD-associated