Anti-CELSR3 Antibody

Evaluated by Immunohistochemistry in human cerebellum and glioma sections.

Immunohistochemistry Analysis: A 1:2000 dilution and a 1:500 dilution of this antibody detected CELSR3 in human cerebellum and glioma sections, respectively.

Detect CELSR3 using this rabbit polyclonal antibody, Anti-CELSR3 Antibody validated for use in IHC.

Research Category
Cell Structure

Research Sub Category
ECM Proteins

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358 kDa calculated

CELSR3, also known as Cadherin family member 11, Epidermal growth factor-like protein 1, EGF-like protein 1 or Flamingo homolog 1, FML1, or Multiple epidermal growth factor like domains protein 2, and encoded by the gene CELSR3/CDHF11, EGFL1, FMI1, KIAA0812, MEGF2, is a cell surface receptor important for cell to cell signaling and positioning particularly during the development of the nervous system. It is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined but may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation, and recent research demonstrates that CELSR3 is critical for proper development of GABA-signaling pathways in the inner retina. As a cadherin member, CELSR3 is localized to the cell membrane.

KLH-conjugated linear peptide corresponding to the cytoplasmic domain within the C-terminus of human CELSR3.

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.