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ABT52

Anti-phospho-Peak Antibody (Tyr665)

Name: Anti-phospho-Peak Antibody (Tyr665)
Brand: MM

from rabbit, purified by affinity chromatography

Synonym(s):

Pseudopodium-enriched atypical kinase 1, Sugen kinase 269, Tyrosine-protein kinase SgK269

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Clone:

polyclonal

Species reactivity:

human

Application:

DB, WB

Citations:

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Properties

biological source

rabbit

Quality Segment

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human

species reactivity (predicted by homology)

porcine (based on 100% sequence homology), rat (based on 100% sequence homology), orangutan (Sumatran; based on 100% sequence homology), mouse (based on 100% sequence homology)

technique(s)

dot blot: suitable, western blot: suitable

NCBI accession no.

NP_079052

UniProt accession no.

Q9H792

shipped in

wet ice

target post-translational modification

phosphorylation (pTyr665)

Gene Information

human ... PEAK1(79834)

Description

General description

220 kDa calculated

Pseudopodium-enriched atypical kinase 1 (Peak1; KIAA2002, or sgk269) is a ubiquitous non-receptor tyrosine kinase that belongs to the NFK3 family. It interacts with actin filaments via its N-terminal actin-targeting region. It also modulates the activity of multiple cytoskeletal regulatory proteins such as paxillin, p130Cas, Erk, and Crk; and mediates cell proliferation and migration via the Ras/Raf/Erk and Src-p130Cas-Crk-Paxillin pathways. Peak1 may play an important role in the progression of tumors.

Immunogen

Epitope: Phosphorylated Tyr665

KLH-conjugated linear peptide corresponding to human Peak phosphorylated at Tyr665.

Application

This phospho-Peak antibody is validated for use in WB & Dot Blot for the detection of the phospho-Peak protein.

Western Blot Analysis: A representative lot was used by an independent laboratory in 293T cells transfected with wildtype GFP-Peak. (Dr. Richard Klemke, University of California-San Diego.)

Biochem/physiol Actions

This antibody recognizes Peak phosphorylated at Tyr665.

Analysis Note

Control
Modified and non modified peptides of phosphorylated and non-phosphorlyated Peak proteins

Evaluated by Dot Blot in modified and non modified peptides of phosphorylated and non-phosphorlyated Peak proteins.

Dot Blot (Specificity) Analysis: A representative lot blocked phospho-Peak (Tyr665) in modified and non modified peptides of phosphorylated and non-phosphorlyated Peak proteins.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c